November 5, 2026·49 min read

Amgen Inc. (AMGN), Financial Analysis

Insights derived from analysing SEC filings. Independent analysis, not a publication of the SEC.

Total revenues Q3 2026
$10.4bn
+8.5% year on year (Q3 2025 $9.56bn)
Operating expenses Q3 2026
$6.66bn
(5.3%) year on year (Q3 2025 $7.03bn)
Operating margin Q3 2026
35.8%
+9.4 pts year on year (Q3 2025 26.4%)
Key findings
  • Q3 2026 total revenues $10.37bn, +8.5%, with product sales $9.88bn, +8.2%, driven by volume (US volume +8%, rest of world +16%). Operating margin 35.8% against 26.4% as acquisition amortization fell and the 2025 Otezla impairment did not recur; GAAP EPS $7.08 against $5.93, non GAAP EPS $6.45 against $5.64.
  • Repatha $1.09bn, +37%, and Evenity $751m, +39%, together 18.6% of product sales against 14.6%. MariTide, Amgen's monthly obesity candidate, is in a Phase 3 program of 10 studies (MARITIME); Amgen has filed no readout dates.
  • Rare disease $1.61bn, +20%, led by Uplizna $451m (+191%) and Krystexxa (+31%); Tezspire $538m, +43%. Enbrel +5% with net selling price 14% lower under its Medicare Part D price since 1 Jan 2026; Otezla (18%) gets its Medicare price in Jan 2027, and Repatha may be selected as early as Jan 2029.
  • Prolia plus Xgeva fell from $1.68bn to $920m (45%) as denosumab biosimilars entered the US market; Blincyto $496m (+27%), Imdelltra $406m (+128%) and the biosimilars portfolio $977m (+26%) together added $534m year on year against the $758m decline.
  • FY2026 guidance raised for the third time, to revenues of $38.9bn to $39.7bn (Feb 2026: $37.0bn to $38.4bn) and non GAAP EPS of $22.90 to $23.70. Horizon products ($27.8bn deal, Oct 2023) earned $4.62bn in FY2025, while acquisition amortization in cost of sales fell to $881m from $1.42bn. Debt $54.0bn against cash $13.2bn.
  • Events and market: a material cybersecurity incident in third party cloud environments (Item 1.05, 31 Jul 2026), Thomas Dittrich CFO since 1 Sep 2026, officers' open market sales of $29.3m with no purchases. Shares at $476.04 trade at 27.6x TTM GAAP EPS and 20.5x TTM non GAAP EPS; model base case $344 in FY2029 (18x model GAAP EPS of $19.12, against the current 27.6x TTM GAAP P/E), range $181 to $531.

Figures are read from the Forms 10-K for FY2021 to FY2025, the Forms 10-Q for Q1 2025 to Q3 2026 (Q3 filed 3 Nov 2026), the Forms 8-K with all their exhibits, incl. the quarterly earnings releases (Ex 99.1) with their product tables and non GAAP appendices, the notes documents of Feb 2026 (Ex 1.1, 4.2, 5.1), the Kyowa Kirin termination agreement and the CFO offer letter (Ex 10.1, 10.2), the 2026 proxy statement with the Form 8-K Item 5.07 vote results, and Forms 4 for central index key 318154, together with the filings of 13 competitor and peer companies used in chapters 2 to 5. Amgen files no separate CFO commentary; the financial sections of the Q3 2026 release (Ex 99.1) are used in its place. Statements marked as stated on the call come from the Q3 2026 earnings call of 3 Nov 2026. Accession numbers appear in the Sources appendix. Share price is the trade of 5 Nov 2026.

1 Revenue & Business Model

  • Storyline: Amgen grows product volume in newer medicines while older brands lose exclusivity or face Medicare price setting. Repatha, Evenity, Tezspire, Uplizna, Imdelltra and Blincyto together earned $3.73bn in Q3 2026, +53%, against $920m for Prolia plus Xgeva. Chapters 2 to 4 cover the three revenue drivers: Repatha, Evenity and MariTide; rare disease and inflammation; oncology and biosimilars.
  • One operating segment (human therapeutics). FY2025 total revenues $36.75bn: product sales $35.15bn and other revenues (royalties, partner revenue) $1.60bn; 14 products sold above $1bn. McKesson, Cencora and Cardinal Health together accounted for 77% of worldwide gross revenues in 2025 (10-K FY2025).
  • Revenues FY2021 $25.98bn, FY2025 $36.75bn, a 9.1% CAGR, with the Horizon acquisition (closed 6 Oct 2023) adding Tepezza, Krystexxa, Uplizna and ultra rare products. TTM Q3 2026 revenues $38.90bn, +8.2%.
  • Regions: United States 71.9% of FY2025 total revenues against 70.0% in FY2021; in Q3 2026 US product sales were $7.26bn (+7.5%) and rest of world $2.62bn (+10.0%).
  • Horizon products (Tepezza, Krystexxa, Uplizna, ultra rare) earned $4.17bn in FY2024 and $4.62bn in FY2025, and $4.07bn in 9M 2026, +22.1% on 9M 2025.
Figure 1.1 Total revenues and operating margin, FY2021 to TTM Q3 2026
Figure 1.2 Total revenues by product ($bn)
Figure 1.3 Total revenues by region, share
Figure 1.4 Horizon acquired products (Tepezza, Krystexxa, Uplizna, ultra rare) sales, quarterly ($m)
Table 1.1 Sales by product, last five quarters ($m)
ProductQ3 2025Q4 2025Q1 2026Q2 2026Q3 2026Q3 growth (%)
Repatha7948708769531,08536.6
Evenity54159956271475138.8
Prolia1,1391,054727759632(44.5)
Xgeva539447411352288(46.6)
Tezspire37747434348653842.7
Enbrel5805323205806115.3
Tepezza560457490576526(6.1)
Blincyto39241341547249626.5
Otezla585625431491481(17.8)
Nplate4573854124304723.3
Uplizna155233262335451191.0
Krystexxa32043525540041930.9
Imdelltra178234258288406128.1
Vectibix28431928733833518.0
Kyprolis359351330314330(8.1)
Pavblu21325828028730040.8
Aranesp357333311352329(7.8)
Neulasta92132165179195112.0
Amjevita15417417315519124.0
Mvasi213188150153168(21.1)
Tavneos107152119150105(1.9)
Ultra rare products20015798149110(45.0)
Lumakras9692941111026.3
Parsabiv84898710182(2.4)
Total product sales9,1379,3678,2189,5379,8838.2
Other revenues42049940051748214.8
Total revenues9,5579,8668,61810,05410,3658.5
Source: product sales tables of the 8-K Ex 99.1 releases; Q4 2025 from the Q4 2025 release. Selected products, so product lines do not add to total product sales. Tezspire is Amgen's US booking.

2 Repatha, Evenity and MariTide: Volume Growth and an Obesity Program in Phase 3

  • Repatha $1.09bn in Q3 2026, +37%: US $666m (+51%), rest of world $419m. 9M 2026 $2.91bn, +36%. Amgen expects Repatha's net price to fall by about mid single digits in 2026.
  • Repatha outcomes data: in VESALIUS CV (more than 12,000 patients without a prior heart attack or stroke) Repatha cut the risk of three point MACE by 25% and of heart attack by 36%; an Aug 2026 analysis showed a nominal 20% lower all cause mortality; the EU label was expanded in Aug 2026 (8-K Ex 99.1).
  • Evenity $751m, +39%: US $557m, rest of world $194m. Stated on the call: Evenity holds close to 60% volume share of Japan's bone builder category.
  • Weight in the group: Repatha and Evenity earned 18.6% of Q3 2026 product sales against 14.6% a year earlier.
  • MariTide (status as filed, 8-K Ex 99.1 of 3 Nov 2026): MARITIME 1 (obesity without type 2 diabetes) and MARITIME 2 (with type 2 diabetes) ongoing; enrollment complete in MARITIME CV and both sleep apnea studies; MARITIME HF, MARITIME SWITCH (from weekly tirzepatide or semaglutide to dosing every 8 weeks or quarterly) and extension studies enrolling; MARITIME T2D 3 against semaglutide started, with two more Phase 3 type 2 diabetes studies to start in Q4 2026. Dosing starts monthly, with maintenance of as few as four or six doses a year. No readout dates are filed.
  • MariTide Phase 2 (10-K FY2025): in Part 2, most participants who had lost at least 15% of body weight kept it off for a further 52 weeks on lower monthly or quarterly doses; a Phase 2 type 2 diabetes study showed lower HbA1c and weight at 24 weeks. Capex at the North Carolina, Ohio and Puerto Rico sites partly prepares for a possible launch (stated on the call).

How the cholesterol and obesity markets are changing

  • New PCSK9 entrants: FDA approved Merck's Lipfendra (enlicitide), the first once daily oral PCSK9 inhibitor, in Jul 2026, with LDL cholesterol 56% to 59% lower than placebo at week 24 (Merck 8-K Ex 99.1); Novartis Leqvio, dosed twice a year, grew 63% at constant currency to $506m and gained an FDA label update on MACE reduction (Novartis 6-K).
  • Antibody rival: Praluent US net sales $81m, +20.9% (Regeneron), and EUR 156m outside the US, +20.5% (Sanofi), against Repatha $1.09bn.
  • Obesity scale: Lilly Zepbound $5.35bn (+49.2%) and Mounjaro $10.72bn (+64.6%) in Q3 2026 (Lilly 10-Q); Novo Nordisk obesity sales DKK 26.15bn (+22% at CER) incl. the Wegovy pill (DKK 5.39bn) launched in the US on 5 Jan 2026 at US prices of $149 to $299 a month; Novo reported 21% weight loss for CagriSema at week 68 in REDEFINE 9 (Novo 6-K).
  • Pricing policy: the 10-K FY2025 records Amgen's Dec 2025 actions to satisfy the Jul 2025 most favored nation letter and an expanded direct to patient program.
Figure 2.2 PCSK9 product sales by company in Q3 2026
Table 2.1 Cardiometabolic and obesity products against competitors ($m unless stated)
Company and productPeriodSalesGrowth (%)Filed detail
Amgen RepathaQ3 20261,085+36.6US $666m, rest of world $419m
Novartis LeqvioQ3 2026506+63.0PCSK9 siRNA dosed twice a year; growth at constant currency
Regeneron Praluent (US)Q3 202681+20.9PCSK9 antibody, US net sales
Sanofi Praluent (outside US)Q3 2026EUR 156m+20.5PCSK9 antibody outside the US
Merck Lipfendra (enlicitide)Q2 2026not filednot filedfirst oral PCSK9 inhibitor, FDA approval Jul 2026
Amgen EvenityQ3 2026751+38.8US $557m, rest of world $194m
Eli Lilly ZepboundQ3 20265,352+49.2tirzepatide for obesity; Mounjaro $10.72bn, +64.6%
Novo Nordisk obesityQ3 2026DKK 26.15bn+22.0growth at CER; Wegovy pill DKK 5.39bn after its 5 Jan 2026 US launch
Amgen MariTideQ3 2026no salesn/aPhase 3 MARITIME program; no readout dates filed
Sanofi in EUR and Novo Nordisk in DKK, growth at constant exchange rates; Leqvio growth at constant currency. Merck filed no Lipfendra sales figure.

3 Rare Disease and Inflammation: Uplizna and Tezspire Grow as Medicare Prices Reach Enbrel and Otezla

  • Rare disease $1.61bn in Q3 2026, +20%: Uplizna $451m (+191%) after its US approval in generalized myasthenia gravis (Dec 2025); Krystexxa $419m (+31%); Tepezza $526m, (6%), which management attributed on the call to a prior year inventory build; Tavneos $105m.
  • Tezspire $538m, +43% (Amgen books US sales; AstraZeneca books the rest); the Phase 3 CROSSING study in eosinophilic esophagitis was positive. Stated on the call: US new to brand prescriptions up 15% against about 3% market growth.
  • Enbrel $611m, +5%, with net selling price 14% lower in Q3 2026 under the Medicare Part D price set from 1 Jan 2026, after 15% lower in Q1 and 22% lower in Q2; 9M 2026 (11%).
  • Otezla $481m, (18%): rest of world sales fell 53% after generic entry in certain European countries in Q1 2026; the Medicare Part D price applies from Jan 2027, after $1.2bn of intangible impairments in 2025.
  • Tavneos: CDER proposed on 27 Apr 2026 to withdraw the US approval; Amgen requested a hearing and its 23 Jul 2026 submission awaits CDER; the EU authorization was revoked in Aug 2026.

How the rare disease and inflammation markets are changing

  • Medicare price setting: CMS sets prices for 10 Part D drugs from 1 Jan 2026, 15 more in 2027 and 2028 and 20 a year from 2029, about 100 drugs by 2031 (10-Q Q3 2026). Enbrel's price applies from 2026, Otezla's from 2027, and Repatha may be selected as early as Jan 2029.
  • Myasthenia gravis: argenx Vyvgart, an FcRn blocker, reached $1.72bn of product net sales in Q3 2026, +52.7%, and filed an sBLA in ocular myasthenia gravis (argenx 6-K), against Uplizna $451m.
  • Respiratory and eosinophilic disease: AstraZeneca booked Tezspire sales of $429m outside the US, +50.0% (AstraZeneca 6-K); Sanofi Dupixent, already approved in eosinophilic esophagitis, sold EUR 5.69bn, +34.8% at CER (Sanofi 6-K).
  • Immunology peers: AbbVie immunology $9.17bn, +16.3% (AbbVie 8-K); Novartis Cosentyx $1.86bn, +9.0% at constant currency (Novartis 6-K).
Figure 3.2 Growth year on year of Enbrel, Otezla, Tezspire and Krystexxa by quarter
Figure 3.3 Inflammation and rare disease sales by company in Q3 2026
Table 3.1 Rare disease and inflammation products against competitors ($m unless stated)
Company and productPeriodSalesGrowth (%)Filed detail
Amgen UpliznaQ3 2026451+191.0gMG approval Dec 2025; US $352m
argenx VyvgartQ3 20261,721+52.7FcRn blocker in gMG and CIDP
Amgen Tezspire (US)Q3 2026538+42.7Amgen books US sales
AstraZeneca TezspireQ3 2026429+50.0AstraZeneca books sales outside the US
Sanofi DupixentQ3 2026EUR 5.69bn+34.8approved in eosinophilic esophagitis; growth at CER
Amgen EnbrelQ3 2026611+5.3net selling price 14% lower under the Medicare Part D price
Amgen OtezlaQ3 2026481(17.8)rest of world (53%) after European generics; Medicare price from Jan 2027
AbbVie immunologyQ3 20269,165+16.3Skyrizi, Rinvoq and Humira
Novartis CosentyxQ3 20261,857+9.0growth at constant currency
Amgen TepezzaQ3 2026526(6.1)thyroid eye disease; US $441m
Amgen KrystexxaQ3 2026419+30.9uncontrolled gout; US only
Sanofi in EUR with growth at constant exchange rates; argenx growth computed from product net sales. Amgen and AstraZeneca Tezspire are separate bookings of one collaboration product.

4 Oncology and Biosimilars: BiTE Growth and Pavblu Against Denosumab Biosimilar Erosion

  • Prolia plus Xgeva $920m in Q3 2026 against $1.68bn, (45%): Prolia $632m (45%, volume 23% lower), Xgeva $288m (47%, volume 32% lower, net price 11% lower). US RANKL antibody patents expired in Feb 2025 and select European patents in Nov 2025; Amgen expects further erosion in 2026.
  • Oncology sales $2.14bn, +21% (Blincyto, Imdelltra, Vectibix, Kyprolis, Lumakras, Nplate): Blincyto $496m (+27%) and Imdelltra $406m (+128%), with rest of world Imdelltra $182m after EU approval in May 2026.
  • Imdelltra: full FDA approval in second line extensive stage small cell lung cancer (Nov 2025); in Sep 2026 FDA cut the monitoring time for the first two doses to 6 to 8 hours from 22 to 24 hours; DeLLphi 305 with AstraZeneca's Imfinzi showed median overall survival of 21.1 months against 12.7 months for Imfinzi alone (stated on the call).
  • Biosimilars portfolio $977m, +26%: Pavblu $300m (+41%, volume +71%, net price 18% lower), Amjevita $191m, Mvasi $168m. FY2025 biosimilars $3.0bn.
  • Net effect: Blincyto, Imdelltra and biosimilars added $534m of quarterly sales year on year against a $758m fall in Prolia plus Xgeva.

How the oncology and biosimilar markets are changing

  • Denosumab biosimilars: Organon sold $24m of its Prolia and Xgeva biosimilars (Bildyos, Bilprevda) in Q3 2026 against $3m in Q3 2025, their launch quarter, and $60m in 9M 2026 (Organon 10-Q).
  • Aflibercept: Regeneron US EYLEA 2 mg sales fell 41.3% to $400m while EYLEA HD rose 62.2% to $699m (Regeneron 8-K); Pavblu grew to $300m.
  • Biosimilar pipeline against large reference products: ABP 206 (Opdivo) is under FDA review with action expected by end 2026; ABP 234 (Keytruda, $8.60bn of Merck sales in Q3 2026, +5.6%) met its primary endpoints and was submitted; ABP 938 targets EYLEA HD (Amgen 8-K Ex 99.1).
  • Oncology peers: AstraZeneca Imfinzi $1.99bn, +24% (partner drug in DeLLphi 305); J&J oncology $7.60bn, +16.4%, in the quarter to 27 Sep 2026; Pfizer oncology $4.33bn, +9.9%.
Figure 4.2 Oncology and biosimilar product sales by company in Q3 2026
Table 4.1 Oncology and biosimilar products against competitors ($m)
Company and productPeriodSalesGrowth (%)Filed detail
Amgen ProliaQ3 2026632(44.5)US RANKL antibody patents expired Feb 2025
Amgen XgevaQ3 2026288(46.6)same molecule (denosumab), oncology use
Organon Bildyos and BilprevdaQ3 202624n/mdenosumab biosimilars launched in Q3 2025; Q3 2025 $3m; $60m in 9M 2026
Amgen PavbluQ3 2026300+40.8aflibercept biosimilar; US $294m
Regeneron EYLEA and EYLEA HD (US)Q3 20261,099(1.2)reference product for Pavblu; EYLEA 2 mg $400m, (41.3%)
Amgen BlincytoQ3 2026496+26.5BiTE in B cell leukemia; rest of world $227m
Amgen ImdelltraQ3 2026406+128.1BiTE in small cell lung cancer; rest of world $182m
AstraZeneca ImfinziQ3 20261,990+24.0partner drug in DeLLphi 305
Merck Keytruda familyQ3 20268,601+5.6reference product for ABP 234
J&J oncologySep 2026 quarter7,602+16.4quarter to 27 Sep 2026
Pfizer oncologyQ3 20264,327+9.92026 portfolio definition
Organon growth is not meaningful against $3m in the Q3 2025 launch quarter. J&J quarter ends 27 Sep 2026.

5 Financial Analysis & Ratios

  • TTM Q3 2026 operating income $12.61bn, 32.4% of total revenues, against 24.7% in FY2025, as amortization of acquired intangibles (mainly Horizon) in cost of sales declined. Amgen's non GAAP operating margin, which excludes that amortization, was 47.3% of product sales in Q3 2026 and 46.1% in FY2025.
  • Net income TTM $9.39bn, GAAP diluted EPS $17.24, non GAAP EPS $23.17. Other income swings with the fair value of the BeOne stake (about 17%, $6.9bn at 30 Sep 2026): Q3 2026 included an unrealized gain of $1.5bn.
  • Cash flow TTM Q3 2026: operating cash flow $12.04bn, capex $2.45bn, free cash flow $9.58bn (24.6% of revenues), dividends $5.37bn, no buybacks. Q3 2026 free cash flow $3.65bn against $4.25bn, when Q3 2025 benefited from rebate and collection timing (8-K Ex 99.1).
  • Balance sheet at 30 Sep 2026: debt $54.0bn against $64.6bn at end 2023 after the Horizon financing; cash $13.2bn; net debt $40.8bn; equity $14.4bn; goodwill $18.7bn and intangibles $19.5bn.
  • Capital returns: quarterly dividend $2.52 (+6%), declared again in Oct 2026; no buybacks in 2025 or 9M 2026, with $6.8bn of authorization left and FY2026 repurchases capped at $3.0bn.
Table 5.1 Income statement, cash flow and balance sheet summary ($bn unless stated)
Line itemFY2021FY2022FY2023FY2024FY2025TTM Q3 2026
Revenue26.026.328.233.436.838.9
Gross profit19.519.919.720.624.727.6
Research and development4.84.44.86.07.37.8
Selling, general and administrative5.45.46.27.17.17.0
Operating income7.69.67.97.39.112.6
Net income5.96.66.74.17.79.4
Diluted EPS ($)10.2812.1112.497.5614.2317.24
Operating cash flow9.39.78.511.510.012.0
Capital expenditure(0.9)(0.9)(1.1)(1.1)(1.9)(2.5)
Free cash flow8.48.87.410.48.19.6
Stock based compensation0.30.40.40.50.50.5
Cash and investments8.09.310.912.09.113.2
Total debt33.338.964.660.154.654.0
Total equity6.73.76.25.98.714.4
TTM column: Q4 2025 plus 9M 2026 for income and cash flow; balance sheet lines at 30 Sep 2026. Operating income as reported. Cost of sales and gross profit include amortization of acquired intangibles and, in FY2023 to FY2025, the Horizon inventory step up. Equity is low against assets after buybacks of $4.98bn (FY2021) and $6.36bn (FY2022).
Figure 5.1 Quarterly revenue and margins
Table 5.2 What changed, Q3 2026 against Q3 2025
MetricQ3 2025Q3 2026Change
Revenue ($bn)9.5610.378.5%
Gross profit ($bn)6.487.5817.0%
Operating income ($bn)2.533.7146.9%
Net income ($bn)3.223.8620.1%
Diluted EPS ($)5.937.0819.4%
Operating cash flow ($bn)4.684.24(9.5%)
Free cash flow ($bn)4.253.65(14.0%)
Operating margin (%)26.435.89.4 pts
Net margin (%)33.737.33.6 pts
Table 5.3 Ratio analysis
RatioFY2021FY2022FY2023FY2024FY2025TTM Q3 2026
Growth and margins
Revenue growth (%)n/a1.37.118.610.0n/a
Gross margin (%)75.275.770.061.567.270.9
Operating margin (%)29.436.328.021.724.732.4
Net margin (%)22.724.923.812.221.024.1
FCF margin (%)32.333.426.131.122.024.6
Cost and investment intensity
R&D (%) revenue18.516.817.017.819.820.2
SBC (%) revenue1.31.51.51.61.31.3
Capex (%) revenue3.43.63.93.35.16.3
Effective tax rate (%)12.110.814.511.314.115.0
Returns
ROE (%)88.0126.5135.867.6106.165.4
ROA (%)9.610.48.34.38.59.8
ROIC (%)21.025.611.311.914.419.4
Asset turnover (x)0.420.400.290.360.410.41
Liquidity and leverage
Current ratio (x)1.591.411.651.261.141.48
Debt to equity (x)4.9710.6410.3710.236.313.76
Net cash ($bn)(25.3)(29.6)(53.7)(48.1)(45.5)(40.8)
Efficiency and cash quality
Days sales outstanding697794749597
Inventory days231281411199189206
FCF to net income (x)1.421.341.102.541.051.02
Shareholder returns (%) FCF10712062486356
ROE and ROA use average balances for FY2022 to FY2025 and closing balances for TTM. ROE is high because equity was $3.66bn to $14.35bn over the period. FY2021 operating income includes $1.51bn of acquired IPR&D (Five Prime).
Figure 5.2 Margin profile
Figure 5.3 Operating cash flow, capital expenditure and free cash flow
Table 5.4 Valuation snapshot at $476.04 per share, 5 Nov 2026
MeasureValue
Market cap ($bn)257.5
Enterprise value (net debt at 30 Sep 2026) ($bn)298.3
P/E on TTM Q3 2026 GAAP EPS (x)27.6
P/E on TTM non GAAP EPS (x)20.5
P/E on FY2026 non GAAP EPS guidance midpoint (x)20.4
EV/Sales TTM Q3 2026 (x)7.7
FCF yield on TTM FCF (%)3.7
Price/Book at 30 Sep 2026 (x)17.9
Dividend yield (%)2.1

Cost structure and profitability

  • Gross margin 73.1% of total revenues in Q3 2026 against 67.8%, as the acquisition amortization adjustment in cost of sales fell to $881m from $1.42bn; non GAAP cost of sales rose to 19.3% of product sales from 18.2% on profit share expense and sales mix (8-K Ex 99.1).
  • R&D $2.11bn in Q3 2026, +11.1%, 20.4% of revenues; 9M 2026 R&D $5.70bn against $5.13bn, with later stage programs led by MariTide.
  • SG&A $1.68bn, (2.3%), 16.2% of revenues; other operating expenses $76m against $329m, when Q3 2025 carried the $400m Otezla impairment.
  • Below operating income: interest expense $653m; other income $1.63bn, mainly the BeOne gain; tax $822m on pretax income of $4.69bn (17.5%); non GAAP tax rate 15.9% against 18.2%.
  • Operating margin 35.8% in Q3 2026 against 26.4%; 9M 2026 34.1% against 23.7% in 9M 2025. Amgen reports GAAP operating margin of 37.5% and non GAAP of 47.3% on product sales.
Figure 5.4 Costs as % of total revenues by quarter
Figure 5.5 GAAP and non GAAP diluted EPS by quarter
Table 5.5 Costs as % of total revenues, last five quarters
LineQ3 2025Q4 2025Q1 2026Q2 2026Q3 2026
Cost of sales (% of revenues)32.230.231.828.026.9
Research and development (% of revenues)19.921.719.918.620.4
Selling, general and administrative (% of revenues)18.019.818.617.416.2
Other operating expenses (% of revenues)3.40.8(1.3)1.20.7
Operating income (% of revenues)26.427.630.935.035.8
Net income (% of revenues)33.713.521.123.637.3

Horizon acquisition, amortization and debt

  • Horizon (closed 6 Oct 2023, $27.8bn): developed product technology rights of $19.6bn amortized over about 10 years plus $1.06bn of IPR&D, acquired inventory at a fair value of $5.0bn (step up amortization $1.3bn in FY2025) and goodwill of $3.1bn. Group intangibles fell from $32.6bn at end 2023 to $19.5bn at 30 Sep 2026.
  • Acquisition amortization in cost of sales (non GAAP adjustment, Horizon the largest part): $881m in Q3 2026 against $1.42bn, and $2.96bn in 9M 2026 against $4.43bn.
  • Debt: $64.6bn at end 2023, $60.1bn at end 2024, $54.6bn at end 2025 and $54.0bn at 30 Sep 2026; the 10-K states that Amgen has substantially returned to its pre acquisition capital structure. Interest expense $3.16bn in FY2024, $2.76bn in FY2025 and $1.98bn in 9M 2026.
  • Feb 2026 notes: $4.0bn in four tranches at 4.20% (2031), 4.85% (2036), 5.50% (2046) and 5.65% (2056); principal maturities at end 2025 were $4.57bn in 2026 and $2.72bn in 2027.
Figure 5.6 Debt, intangible assets and cash by year end
Table 5.6 Horizon products sales ($m)
ProductFY2023 (from 6 Oct)FY2024FY20259M 2026
Tepezza4481,8511,9031,592
Krystexxa2721,1851,3401,074
Uplizna653796551,048
Ultra rare products164758719357
Total, four lines9494,1734,6174,071
Table 5.7 Debt principal maturities at 31 Dec 2025 ($m)
YearPrincipal
20264,571
20272,724
20284,984
20292,943
20304,000
thereafter36,822
Total principal56,044
Source: 10-K FY2025 debt note. In 9M 2026 Amgen repaid $3.9bn and issued $4.0bn.

6 MD&A & Management Commentary

Q3 2026 results release and Form 10-Q (3 Nov 2026)

  • Q3 2026: total revenues $10.37bn, +8.5%; product sales $9.88bn, +8.2%: US $7.26bn (+8%) and rest of world $2.62bn (+10%) on US volume +8% and rest of world volume +16%; other revenues $482m (+15%) on royalties and partner revenue (10-Q).
  • Costs (10-Q): operating expenses $6.66bn, (5.3%), on lower acquisition amortization and the absence of the $400m Otezla impairment of Q3 2025; cost of sales 26.9% of revenues against 32.2%; R&D $2.11bn, +11.1%, with later stage spending mainly on MariTide.
  • Products (8-K Ex 99.1 and 10-Q): Enbrel $611m, +5%, with net selling price 14% lower; Otezla $481m, (18%), with rest of world (53%) after generic entry in certain European countries in Q1 2026; Prolia $632m (45%) and Xgeva $288m (47%); Nplate included $65m of US government orders against $90m.
  • Pipeline (8-K Ex 99.1): DeLLphi 305: Imdelltra with Imfinzi cut the risk of death by 58% in first line maintenance small cell lung cancer; dazodalibep met the primary endpoint of the Phase 3 OASIZ 301 study in Sjogren's disease; Tezspire CROSSING positive in eosinophilic esophagitis; FDA accepted the BLA for ABP 206 (nivolumab biosimilar); Repatha EU label expanded on VESALIUS CV.
  • Stated on the call (3 Nov 2026): six growth drivers +27% and more than 70% of product sales; 17 products annualizing above $1bn; Repatha US weekly new to brand prescriptions up more than 60%; Evenity close to 60% volume share of Japan's bone builder category; Tepezza (6%) attributed to a prior year inventory build; management does not expect a step down in the 2027 operating margin against 2026; Q3 was the first call of CFO Thomas Dittrich.
  • Q2 2026 (8-K Ex 99.1 of 4 Aug 2026): total revenues $10.05bn, +10%; 22 products grew at least 10%; Enbrel $580m, (4%), with net selling price 22% lower; Prolia $759m, (32%); GAAP EPS $4.37, non GAAP EPS $6.29; revenue guidance raised to $38.2bn to $39.4bn.
  • Q1 2026 (8-K Ex 99.1 of 30 Apr 2026): total revenues $8.62bn, +6%; product sales +4% on 9% volume growth, 2% lower net selling price and 2% lower inventory; Enbrel $320m, (37%); CDER proposed on 27 Apr 2026 to withdraw the Tavneos approval.
Table 6.1 Current outlook items
ItemOutlookSource
FY2026 total revenues$38.9bn to $39.7bn (Aug: $38.2bn to $39.4bn; Feb: $37.0bn to $38.4bn)8-K Ex 99.1, 3 Nov 2026
FY2026 EPSGAAP $18.34 to $19.28; non GAAP $22.90 to $23.70 (Aug: $22.30 to $23.50)8-K Ex 99.1, 3 Nov 2026
FY2026 tax rateGAAP 14.5% to 16.0%; non GAAP 15.0% to 16.5%8-K Ex 99.1, 3 Nov 2026
Capex and buybackscapex about $2.6bn; repurchases not to exceed $3.0bn (none in 9M 2026)8-K Ex 99.1, 3 Nov 2026; 10-Q Q3 2026
Non GAAP operating margin and other revenuesabout 45% to 46% of product sales; other revenues about $1.9bnStated on the Q3 2026 call
Product outlookProlia and Xgeva: further erosion from biosimilars in 2026; Otezla: lower net price from Medicare price setting from 2027; Repatha: net price lower by about mid single digits in 202610-Q Q3 2026 MD&A; 8-K Ex 99.1, 3 Feb 2026

Management and CFO commentary

  • Q3 2026 release, financial sections (8-K Ex 99.1 of 3 Nov 2026; Amgen files no separate CFO commentary): non GAAP cost of sales 19.3% of product sales against 18.2%, on profit share expense and sales mix; non GAAP R&D $2.11bn, +11%, on research and early pipeline spending incl. business development; non GAAP SG&A $1.68bn, (1%); non GAAP tax rate 15.9% against 18.2%.
  • Cash and debt (same release): operating cash flow $4.2bn, capex $0.6bn, free cash flow $3.7bn against $4.2bn, when Q3 2025 benefited from rebate and collection timing; debt $54.0bn against $54.6bn at end 2025; cash $13.2bn against $9.1bn.
  • CEO Robert Bradway (8-K Ex 99.1 of 3 Nov 2026): cites the commercial portfolio, clinical advances and the late stage pipeline as the basis for growth into the next decade; in the Q2 release he reported six growth drivers +26% and nearly 70% of product sales.
  • Stated on the call (3 Nov 2026): FY2026 non GAAP operating margin about 45% to 46% of product sales; other revenues about $1.9bn; FY2026 capex about $2.6bn incl. North Carolina, Ohio and Puerto Rico; no step down expected in the 2027 operating margin against 2026.
  • CFO change (8-K of 19 May 2026): Peter Griffith, CFO since 2020, stepped down on 31 Aug 2026 and stays until 31 Jan 2027; Thomas Dittrich, 62, joined on 1 Jul 2026 and became CFO on 1 Sep 2026.
Table 6.2 Management statements in their own words
SpeakerDate and sourceStatement
Robert A. Bradway, Chairman and CEO3 Nov 2026, 8-K Ex 99.1“deliver durable growth well into the next decade”
Robert A. Bradway, Chairman and CEO4 Aug 2026, 8-K Ex 99.1“Our six key growth drivers grew 26% year over year”
Robert A. Bradway, Chairman and CEO30 Apr 2026, 8-K Ex 99.1“enabling us to grow through expected patent expirations and increased competition”
Table 6.3 Key disclosures in the Forms 10-K and 10-Q
ItemDisclosure
10-K FY2025, customersMcKesson, Cencora and Cardinal Health each above 10% of revenues; together 77% of worldwide gross revenues in 2025 (77% in 2024, 79% in 2023).
10-K FY2025, HorizonAcquired 6 Oct 2023 for $27.8bn ($116.50 per share); developed product technology rights $19.6bn amortized over about 10 years and IPR&D $1.06bn ($20.7bn together); acquired inventory at fair value $5.0bn; goodwill $3.1bn.
10-K FY2025, OtezlaIntangible impairments of $1.2bn in 2025 after Otezla was selected for Medicare price setting.
10-K FY2025 and 10-Q Q3 2026, IRS disputeUS against Puerto Rico profit allocation: 2010 to 2012 about $3.6bn tax plus interest; 2013 to 2015 about $5.1bn plus interest and $2.0bn of penalties, before offsets of up to $0.9bn and $2.2bn of repatriation tax paid; Tax Court decision expected no earlier than late 2026 or early 2027; similar draft NOPAs for 2016 to 2018 (Apr to Sep 2026).
10-Q Q3 2026, BeOneStake of about 17% at fair value $6.9bn; Q3 2026 unrealized gain $1.5bn; letter agreement with BeOne Medicines of 10 Jul 2026 filed as Ex 10.20.8.
10-Q Q3 2026, legalProlia and Xgeva BPCIA suits against Amneal, Dr. Reddy's and Alkem continue (new patent asserted Oct 2026); Regeneron Pavblu patent suits, claim construction 1 Dec 2026; BMS and Ono sued on 8 Sep 2026 over ABP 206; securities class action settlement preliminarily approved 21 Oct 2026.
10-Q Q3 2026, tariffsSection 232 tariffs on patented pharmaceuticals proclaimed Apr 2026; Amgen has about three years of relief from Dec 2025 tied to US manufacturing investment in Ohio, North Carolina and Puerto Rico.
10-Q Q3 2026, liquidity9M 2026 operating cash flow $10.43bn (9M 2025 included the final $1.8bn repatriation tax payment); capex $1.81bn; dividends $4.08bn; $4.0bn revolver extended to Mar 2029, undrawn.
Table 6.4 FY2026 guidance, all versions
Measure3 Feb 202630 Apr 20264 Aug 20263 Nov 2026
Total revenues ($bn)37.0 to 38.437.1 to 38.538.2 to 39.438.9 to 39.7
Non GAAP diluted EPS ($)21.60 to 23.0021.70 to 23.1022.30 to 23.5022.90 to 23.70
Source: 8-K Ex 99.1 of each results date. 9M 2026 revenues $29.04bn imply Q4 2026 revenues of $9.86bn to $10.66bn against $9.87bn in Q4 2025; 9M 2026 non GAAP EPS $17.88 implies Q4 2026 non GAAP EPS of $5.02 to $5.82 against $5.29.

7 Sector & Competitor Analysis

  • Sector: large biopharmaceutical companies facing Medicare price setting, most favored nation pricing, 340B growth, Section 232 tariffs and biosimilar entry; Amgen has about three years of tariff relief from Dec 2025 tied to US manufacturing investment (10-Q Q3 2026).
  • TTM Q3 2026 revenue growth: AMGN +8.2% against LLY 45.5%, REGN 36.3%, ABBV 10.3%, GILD 6.5%, BMY 5.2%.
  • Operating margin: AMGN 32.4% against LLY 40.3%, ABBV 32.2%, REGN 28.8%, BMY 23.1%, GILD (7.6%); Gilead's margin reflects $11.8bn of acquired IPR&D. FCF margin AMGN 24.6% against GILD 44.5%, ABBV 28.3%, LLY 22.7%, REGN 22.6%, BMY 18.6%.
  • Net debt: AMGN $40.8bn, ABBV $64.3bn, LLY $44.6bn, BMY $29.9bn, GILD $19.8bn; REGN holds net cash of $16.2bn.
  • Valuation: EV/Sales AMGN 7.67x against LLY 15.90x, ABBV 8.62x, GILD 7.47x, REGN 4.82x and BMY 3.15x; P/E on TTM GAAP EPS AMGN 27.6x, on TTM non GAAP EPS 20.5x.
  • Obesity: Lilly TTM revenues $86.5bn, +45.5%, mainly incretin medicines, with an operating margin of 40.3%; MariTide is in Phase 3 with no filed readout dates.
Table 7.1 Peer comparison, TTM Q3 2026
CompanyRevenue TTM ($bn)Revenue growth (%)Gross margin (%)Operating margin (%)Net margin (%)FCF margin (%)ROE (%)Net cash ($bn)Market value ($bn)EV/Sales (x)P/E TTM (x)
AMGN38.98.270.932.424.124.678.4(40.8)2587.727.6
REGN16.936.385.828.828.522.614.916.2984.820.8
GILD31.06.579.9(7.6)(12.5)44.5n/a(19.8)2127.5n/a
LLY86.545.583.640.331.922.782.6(44.6)1,33115.945.9
ABBV66.010.373.732.215.728.3n/a(64.3)5058.649.2
BMY50.05.269.223.118.518.644.1(29.9)1283.213.8
Peer metrics are TTM Q3 2026 from each company's Forms 10-Q and 8-K, built with the same method. Amgen growth is against prior TTM revenues of $35.97bn; Amgen P/E on TTM non GAAP EPS of $23.17 is 20.5x. Amgen ROE uses average equity of 30 Sep 2025 and 30 Sep 2026 (65.4% on closing equity in Table 5.3). Gilead margins and P/E reflect $11.8bn of acquired IPR&D; ROE is not meaningful for Gilead (loss) and AbbVie (negative equity). Market values at prices of 2 to 5 Nov 2026.
Figure 7.1 Revenue growth versus operating margin, peer set

8 Material Events & Contracts

  • 12 Forms 8-K between 4 Nov 2025 and 5 Nov 2026: five results releases (Ex 99.1), the Feb 2026 notes, the Kyowa Kirin termination, three officer and director filings (CTO, CFO, new director), the annual meeting vote results and the Item 1.05 cybersecurity incident; no Form 8-K/A.
  • Cybersecurity incident (Item 1.05, 31 Jul 2026): Amgen identified unauthorized activity involving data in cloud environments hosted by third party providers; some data, incl. proprietary data and patient protected health information, was exfiltrated. Amgen deemed the incident material on 29 Jul 2026 based on the volume and possible sensitivity of the files and stated that, as of the filing date, it is not reasonably likely to have a material impact on its financial condition or results; no amended filing followed up to 5 Nov 2026.
  • Kyowa Kirin (Item 1.02, 30 Jan 2026): Amgen ended its participation in rocatinlimab, and Kyowa Kirin takes over worldwide development and commercialization at its own cost.
  • Funding: the $4.0bn of notes of 19 Feb 2026 and repayments of $3.9bn in 9M 2026 ($1.8bn term loan, $1.25bn of 2.60% 2026 notes and EUR 750m of 2.00% 2026 notes) left debt at $54.0bn on 30 Sep 2026 against $54.6bn at end 2025; Amgen also repurchased $324m of principal for $233m.
Table 8.1 Forms 8-K filed between 4 Nov 2025 and 5 Nov 2026
DateItemsEvent
4 Nov 20252.02, 9.01Q3 2025 results: revenues $9.6bn (+12%), GAAP EPS $5.93, non GAAP EPS $5.64; FY2025 revenue guidance raised to $35.8bn to $36.6bn. Ex 99.1.
30 Jan 20261.02, 9.01Termination agreement with Kyowa Kirin ending the 1 Jun 2021 licence and collaboration agreement for rocatinlimab; effective on regulatory approval. Ex 10.1.
3 Feb 20262.02, 9.01Q4 and FY2025 results: FY2025 revenues $36.75bn (+10%), GAAP EPS $14.23, non GAAP EPS $21.84, free cash flow $8.1bn; FY2026 guidance revenues $37.0bn to $38.4bn, non GAAP EPS $21.60 to $23.00. Ex 99.1.
19 Feb 20261.01, 9.01$4.0bn of senior notes due 2031, 2036, 2046 and 2056 at 4.20% to 5.65%; net proceeds about $3.96bn. Ex 1.1 underwriting agreement, Ex 4.2 officer's certificate, Ex 5.1 legal opinion.
22 Apr 20265.02, 9.01EVP and CTO David Reese to retire on 30 Jun 2026; his responsibilities move to James Bradner (R&D, AI and Data), Murdo Gordon (Global Markets and Policy) and Peter Griffith from 1 Jun 2026. Ex 99.1.
30 Apr 20262.02, 9.01Q1 2026 results: revenues $8.62bn (+6%), GAAP EPS $3.34, non GAAP EPS $5.15; FY2026 revenue guidance $37.1bn to $38.5bn. Ex 99.1.
19 May 20265.02, 9.01CFO Peter Griffith steps down as CFO on 31 Aug 2026 and retires on 31 Jan 2027; Thomas Dittrich EVP and CFO from 1 Sep 2026. Ex 99.1 release, Ex 10.1 offer agreement, Ex 10.2 expatriate assignment letter.
20 May 20265.07Annual meeting of 19 May 2026: 12 directors elected, say on pay approved, Ernst & Young ratified, independent chair proposal rejected.
31 Jul 20261.05Material cybersecurity incident: unauthorized activity in third party cloud environments identified in Jul 2026; proprietary data and patient protected health information exfiltrated; deemed material on 29 Jul 2026; not reasonably likely to have a material financial impact as of filing.
4 Aug 20262.02, 9.01Q2 2026 results: revenues $10.05bn (+10%), GAAP EPS $4.37, non GAAP EPS $6.29; FY2026 revenue guidance $38.2bn to $39.4bn. Ex 99.1.
26 Oct 20265.02, 9.01David W. Gibbs, CEO of Yum! Brands from 2020 to 2025, appointed director; board at 13 members, 12 independent. Ex 99.1.
3 Nov 20262.02, 9.01Q3 2026 results: revenues $10.37bn (+8%), GAAP EPS $7.08, non GAAP EPS $6.45, free cash flow $3.7bn; FY2026 revenue guidance $38.9bn to $39.7bn. Ex 99.1.
Table 8.2 Material contracts and financing arrangements
ContractTerms
Senior notes, Feb 2026 (Ex 1.1, 4.2, 5.1)$4.0bn: $1.0bn 4.200% due 2031, $1.75bn 4.850% due 2036, $500m 5.500% due 2046, $750m 5.650% due 2056; underwriters BofA Securities, Citigroup, J.P. Morgan and Morgan Stanley; issued under the 22 May 2014 indenture with The Bank of New York Mellon Trust Company; repurchase at 101% on a change of control triggering event; net proceeds about $3.96bn.
Kyowa Kirin termination agreement (Ex 10.1, 30 Jan 2026)Ends the 1 Jun 2021 licence and collaboration agreement for rocatinlimab; Kyowa Kirin takes sole responsibility, at its own cost, for worldwide development, manufacture and commercialization; effective after HSR waiting periods; outside date 1 Apr 2026, extendable for a government shutdown to no later than 1 Jun 2026 unless both parties agree.
CFO offer agreement (Ex 10.1, 10.2, 19 May 2026)Thomas Dittrich: base salary CHF 1.07m, target bonus 100% of salary; 2026 long term incentive CHF 4.5m; one time RSU award CHF 4.7m and cash bonus CHF 4.0m for forgone Galderma pay; two year retention bonus CHF 5.8m; relocation allowance CHF 250,000; employed first by Amgen (Europe) GmbH in Switzerland, with employment moving to Amgen International AG on relocation to Thousand Oaks under the expatriate assignment letter.
Horizon acquisition (6 Oct 2023)$27.8bn consideration ($116.50 per share), $26.7bn in cash, funded mainly with $27.78bn of long term debt issued in FY2023; the $1.8bn term loan was repaid in full in 9M 2026.
Revolving credit facility and swaps$4.0bn unsecured revolver extended to Mar 2029, undrawn at 30 Sep 2026; interest rate swaps of $6.7bn notional (fixed to SOFR) and cross currency swaps of $2.7bn notional (10-K FY2025).
BeOne Medicines letter agreement (10-Q Q3 2026, Ex 10.20.8)Dated 10 Jul 2026 and filed with the Q3 2026 Form 10-Q; Amgen holds about 17% of BeOne at a fair value of $6.9bn.

9 Ownership, Voting Power & Annual Meeting

  • One class of common stock, one vote per share, no controlling holder. The 2026 proxy lists BlackRock (40.8m shares, 7.6%) and State Street (29.5m shares, 5.5%) above 5%, based on Schedules 13G/A; directors and executive officers as a group (21) held 2.73m shares incl. 1.85m obtainable within 60 days, under 1%. Proxy access at 3% for 20 holders; 15% threshold for written consent and special meetings.
  • 2026 annual meeting (19 May 2026): all 12 directors elected with 94.8% (Greg Garland) to 99.3% (Brian Druker) of votes cast; Chairman and CEO Robert Bradway 95.0%; say on pay 97.1%; Ernst & Young 94.1%; the independent chair proposal received 17.7%. David W. Gibbs joined the board on 26 Oct 2026 (13 directors, 12 independent).
  • Insiders, Forms 4 from 7 Nov 2025 to 13 Aug 2026 (none filed later): no open market purchases; open market sales by officers of about $29.3m, mostly after option exercises; the largest was EVP Operations Esteban Santos (54,792 shares at $379.12, about $20.8m, 26 Feb 2026). CEO Bradway exercised 119,782 options with shares withheld for tax and made no open market sale.
  • Officers: CTO David Reese retired on 30 Jun 2026 and his responsibilities were split between James Bradner (EVP, R&D, AI and Data), Murdo Gordon (EVP, Global Markets and Policy) and the CFO; Peter Griffith stepped down as CFO on 31 Aug 2026 and stays as EVP until 31 Jan 2027; Thomas Dittrich, former CFO of Galderma, Shire and Sulzer and Amgen Chief Accounting Officer from 2010 to 2014, became CFO on 1 Sep 2026.
Table 9.1 Annual meeting vote results, 19 May 2026
ProposalFor (bn votes)Against (bn votes)Abstain (bn votes)For as % of votes castResult
Director: Robert A. Bradway0.3900.0200.00295.0Elected
Director: Greg C. Garland0.3910.0210.00194.8Elected
Director: Robert A. Eckert0.3930.0190.00195.3Elected
Advisory vote on executive compensation0.3990.0120.00297.1Approved
Ratify Ernst & Young as auditor for FY20260.4480.0280.00194.1Approved
Shareholder: independent board chair0.0730.3380.00217.7Not approved
Three of 12 directors shown: the two with the lowest support and Robert Eckert. Broker non votes 63.7m on each item except the auditor ratification.
Table 9.2 Holders above 5% in the 2026 proxy statement
HolderShares (m)Share of class (%)Source
BlackRock, Inc.40.87.62026 proxy (Schedule 13G/A of 17 Apr 2025)
State Street Corporation29.55.52026 proxy (Schedule 13G/A of 30 Jan 2024)
Table 9.3 Insider transactions, 12 months to 5 Nov 2026 (Forms 4)
InsiderRoleDateTypeShares and priceValue ($m)
Esteban SantosEVP Operations26 Feb 2026Option exercise and sale54,792 at $379.1220.8
Murdo GordonEVP12 Nov 2025Sale6,879 at $336.832.3
Nancy GrygielSVP6 Aug 2026Option exercise and sale2,970 at $402.161.2
Derek MillerSVP Human Resources6 Aug 2026Option exercise and sale3,890 at $402.541.6
Rachna KhoslaSVP Business Development11 to 13 Aug 2026Sale3,252 at $412.57 to $416.43about 1.3
Robert A. BradwayChairman and CEO4 Mar 2026Option exercise119,782 at $156.35; 84,285 withheld at $379.27not open market
Open market sales totalled about $29.3m over the period; no open market purchases. Other Forms 4 cover award grants, tax withholding and gifts.

10 Risk Factors

  • Item 1A of the FY2025 Form 10-K holds 28 risk factors, as in FY2024 (22,258 words against 22,916): none added or removed, 13 materially reworded and 15 unchanged. The rewording centres on US pricing (most favored nation, OB3, Medicare price setting), tariffs and AI. The 2026 Forms 10-Q add product specific text: Tavneos withdrawal proceedings, the CMS GENEROUS Medicaid model and a Krystexxa drug substance supplier in Israel.
Table 10.1 Risk factors and legal matters with filed figures
RiskDisclosure and change
Medicare price settingEnbrel Part D price since 1 Jan 2026 (net selling price 19% lower in 9M 2026); Otezla from Jan 2027; Repatha may face price setting as early as Jan 2029 (10-Q Q3 2026). CMS sets prices for 10 drugs from 2026, 15 more in each of 2027 and 2028 and 20 a year from 2029. Repatha Q3 2026 sales $1.09bn.
Medicaid, 340B and state actionsCMS GENEROUS Medicaid rebate model (all 50 states applied, Sep 2026); HRSA 340B rebate pilot for Enbrel and Otezla from Jan 2027; Colorado upper payment limit on Enbrel preliminarily enjoined; Washington PDAB selected Otezla on 16 Sep 2026; Colorado drug importation authorized Jun 2026.
Tavneos approvalFDA asked for a voluntary US withdrawal on 16 Jan 2026; CDER proposed withdrawal on 27 Apr 2026; Amgen requested a hearing on 1 Jun 2026 and filed materials on 23 Jul 2026, which await CDER; the European Commission revoked the EU authorization in Aug 2026. Sales $459m in FY2025 and $105m in Q3 2026; the product stays on the US market during the process.
Biosimilar competitionUS RANKL antibody patents expired Feb 2025 and select European patents Nov 2025; Prolia plus Xgeva $920m in Q3 2026 against $1.68bn; BPCIA suits against Amneal, Dr. Reddy's and Alkem continue.
IRS tax disputeAbout $8.7bn of tax plus interest and $2.0bn of penalties claimed for 2010 to 2015, before offsets of up to $3.1bn of repatriation tax paid; Tax Court decision expected no earlier than late 2026 or early 2027; similar draft NOPAs for 2016 to 2018.
CybersecurityItem 1.05 incident (31 Jul 2026): proprietary data and patient protected health information exfiltrated from third party cloud environments; no effect found on products, manufacturing or financial reporting systems; the cyber factor now names AI orchestrated attacks.
Manufacturing and supplyConcentration of manufacturing in Puerto Rico with grid instability; Krystexxa drug substance made by a contract manufacturer in Israel affected by the conflict with Iran; Jun 2026 recalls of Kyprolis lots (Turkey) and Corlanor and Sensipar lots (US) (10-Q Q2 2026).
Customer concentrationThree US wholesalers accounted for 77% of worldwide gross revenues in 2025.

How risk factors changed

  • Comparison: 10-K FY2025 filed 13 Feb 2026 acc 0000318154-26-000010 against 10-K FY2024 filed 14 Feb 2025 acc 0000318154-25-000010.
  • All 28 risk factor headings carry over; none added or removed; 13 materially reworded; total words fall 2.9% from 22,916 to 22,258 as dated examples are cut.
  • Most favored nation pricing is named 21 times in FY2025 Item 1A against none a year earlier, and the OB3 law 9 times against none.
  • Tariffs are named 23 times in 4 risk factors against 2 times in 2 factors in FY2024; AI 18 times against 13, now incl. AI orchestrated cyberattacks and state AI laws.
  • COVID references fall from 10 to 1 and Horizon references from 15 to 7.
  • Through 2026 the Forms 10-Q add product specific exposure: Tavneos withdrawal proceedings, the CMS GENEROUS Medicaid model, Otezla and possibly Repatha (as early as Jan 2029) Medicare price setting, and a Krystexxa drug substance supplier in Israel.
Figure 10.1 Risk factors by change against the prior filing
Table 10.2 Size of the risk factor section
Measure10-K FY202410-K FY2025
Risk factors (count)2828
Words in Item 1A22,91622,258
Table 10.3 Risk factors added, removed and materially reworded
ChangeRisk factorWhat changed
RewordedCoverage, reimbursement and pricing pressureAdds the 4 Jul 2025 OB3 law and its Medicare, Medicaid and ACA changes, the 12 May 2025 MFN executive order and the 31 Jul 2025 MFN letter sent to Amgen; drops the sentence on budget pressure from the economic downturn and inflation; body grows from 417 to 531 words
RewordedUS federal coverage and reimbursement policiesStates CMS has set Medicare Part D prices for Enbrel (from Jan 2026) and Otezla (from Jan 2027), that CMS may reset prices, and that Amgen announced in Dec 2025 actions satisfying the July MFN letter and an expanded direct to patient program; adds the 15 Apr 2025 executive order on small molecule and biologic treatment and CBO projections of OB3 Medicaid cuts
RewordedState pricing actions and 340BAdds Colorado PDAB's Oct 2025 upper payment limit on Enbrel, effective no earlier than 1 Jan 2027, and Washington PDAB's 16 Jul 2025 selection of Enbrel; the named list of states with 340B contract pharmacy laws expands, states introducing such bills rise from 25 to 30, and FDA steps to ease state drug importation are added
RewordedUS commercial payer actionsRemoves the Repatha access and rebate history, the Tezspire Medicare contractor exclusion example and the FTC statistic that six integrated plans controlled about 94% of prescriptions; body shrinks from 763 to 414 words and cross refers to the wholesaler and PBM concentration factor
RewordedTax liabilities, IRS dispute, OECD and OB3Heading now names OB3; adds Tax Court milestones (post trial briefs 13 Jun 2025, oral argument 16 Jul 2025, reply briefs 10 Oct 2025), an IRS audit of 2019 to 2022 expected to begin in H1 2026, and OECD guidance of 5 Jan 2026 exempting US companies from extraterritorial minimum taxes from 1 Jan 2026
RewordedAcquisitions and integrationDrops the Horizon integration and rare disease commercialization passage; states rating agencies downgraded Amgen after the Horizon debt and that Amgen has substantially returned to its pre acquisition capital structure; body shrinks from 759 to 563 words
RewordedIT breakdown, cyberattack or security breachAdds AI enabled tools and AI orchestrated attacks, citing a documented case of an AI agent running a large intrusion campaign, reliance on third parties for identity and access management, and a Nov 2025 third party incident; replaces named past incidents (Okta 2022, a vendor breach covering 1.7m patients) with general wording and adds state AI laws
RewordedDoing business internationallyHeading adds new markets; adds the BIOSECURE Act signed in Dec 2025, tariffs that raised production costs to a limited degree in 2025, and the effect of non US prices on MFN calculations
RewordedAccess to capital and credit marketsRemoves the reference to debt raised for the 2023 Horizon acquisition limiting financing; states Amgen expects to access capital markets from time to time; body shrinks from 335 to 232 words
RewordedBiosimilar and generic competitionAdds FDA and EMA support for streamlined biosimilar approval without routine comparative efficacy studies and EU interchangeability clarity; removes detailed US history (first interchangeable 2021, Jun 2024 draft guidance, umbrella exclusivity, USMCA data exclusivity); body shrinks from 1,381 to 1,033 words
RewordedPuerto Rico manufacturing concentrationReplaces the dated list of Hurricanes Maria (2017) and Fiona (2022), the 2020 earthquakes, the 31 Dec 2024 island outage and COVID lockdowns with general wording on grid instability and reliance on own power generation; body halves from 702 to 354 words
RewordedSustainability objectivesHeading changes from 'environmental, social and governance objectives' to 'sustainability objectives'; removes the figure of at least 16 states with laws barring ESG factors in pension investing
RewordedGlobal economic conditionsAdds the 2 Apr 2025 tariff order (10% universal tariff, higher rates on about 60 countries, pharmaceuticals partly exempt), the 24 Oct 2025 Section 301 investigation of China and tariffs that raised costs to a limited extent; removes COVID recession, debt ceiling and Ukraine inflation passages
Table 10.4 Risk factor updates in quarterly reports since the annual filing
FilingChange disclosed
10-Q Q1 2026, filed 30 Apr 2026Restates the pricing, international, cyber, regulatory approval and global economy factors with updates: the Administration's call for Congress to codify MFN terms, Enbrel price setting already cutting profitability and PBM reform; Tavneos added to the regulatory approval factor (FDA request of 16 Jan 2026 to withdraw, Amgen refusal 28 Jan 2026, drug safety communication 31 Mar 2026, CDER withdrawal proposal 27 Apr 2026); Middle East conflict effects on shipping, airspace and energy, and nation state cyber threats and AI tool reliability
10-Q Q2 2026, filed 4 Aug 2026Adds the CMS GENEROUS Medicaid rebate model, the preliminary injunction on Colorado's Enbrel price limit and FDA authorization of Colorado drug importation (Jun 2026); the cyber factor cites the cloud data theft disclosed in the 31 Jul 2026 8-K; the manufacturing factor adds the Krystexxa drug substance CMO in Israel affected by the conflict with Iran and Jun 2026 recalls of Kyprolis lots (Turkey) and Corlanor and Sensipar lots (US)
10-Q Q3 2026, filed 3 Nov 2026Updates only the pricing and regulatory approval factors: Repatha may face Medicare price setting as early as Jan 2029, Washington PDAB selected Otezla on 16 Sep 2026, HRSA approved a 340B rebate pilot for Enbrel and Otezla from Jan 2027, 23 states have 340B mandate laws; Tavneos: Amgen's 23 Jul 2026 submission awaits CDER and the European Commission revoked the EU authorization in Aug 2026

11 Stock Price, Scenarios & Sensitivity

  • AMGN traded at $476.04 on 5 Nov 2026, +59.5% on the Oct 2025 month end close of $298.43, 1.3% below the 52 week high of $482.48 and 55.7% above the low of $305.80; market value $257.5bn.
  • Valuation: 27.6x TTM GAAP EPS of $17.24; 20.5x TTM non GAAP EPS of $23.17; 20.4x the FY2026 non GAAP EPS guidance midpoint of $23.30; EV/Sales 7.67x; free cash flow yield 3.7%; dividend yield 2.1% on $10.08 a year.
  • Scenario model: revenues grow from TTM Q3 2026 for three years to FY2029; margin is GAAP operating margin (32.4% TTM, 24.7% FY2025), which rises as acquisition amortization falls; interest and other expense $2.6bn a year (TTM interest expense $2.64bn), BeOne fair value changes excluded; 15% tax rate; 546m diluted shares; price equals FY2029 model GAAP EPS times exit P/E. EPS basis: the exit P/E multiples of 14x, 18x and 22x apply to model GAAP EPS; on the same basis the current P/E is 27.6x TTM GAAP EPS of $17.24 (20.5x on TTM non GAAP EPS of $23.17).
Figure 11.1 AMGN monthly closing price and three year scenarios

Critical factors and core assumptions

Table 11.1 Critical factors behind the best case
FactorCurrent valueBest case requiresEvidence in filings and calls
MariTide Phase 3 outcome and timingMARITIME 1 and 2 ongoing; CV and both sleep apnea studies fully enrolled; no readout date filedweight loss competitive with tirzepatide and approval of monthly or less frequent dosing by 2028 or 20298-K Ex 99.1 of 3 Nov 2026; 10-K FY2025 Phase 2 Part 2 data
Repatha growthQ3 2026 $1.09bn, +37%; 9M 2026 $2.91bnVESALIUS CV label expansion adds US volume; no Medicare selection for 202910-Q Q3 2026; EU approval Aug 2026
Denosumab erosionProlia plus Xgeva Q3 2026 $920m against $1.68bndecline flattens by 202710-Q Q3 2026 MD&A
Price setting and MFNEnbrel net selling price (19%) in 9M 2026; Otezla from 2027no further Amgen products selected before 2029; limited MFN effect10-Q Q3 2026 risk factors
Rare disease and oncology launchesUplizna $451m (+191%), Imdelltra $406m (+128%), Tezspire $538m (+43%)each above $2bn of annual sales8-K Ex 99.1 of 3 Nov 2026
Debt and tax casenet debt $40.8bn; IRS claims pendingfavourable Tax Court ruling; debt below $45bn10-Q Q3 2026
  • Base: TTM Q3 2026 revenues $38.90bn; GAAP operating margin 32.4%; FY2026 revenue guidance $38.9bn to $39.7bn.
  • Best case: +7.0% revenue CAGR as Repatha, Evenity, Tezspire, Uplizna and Imdelltra keep growing at 25% to 40% and MariTide launches by 2028 or 2029; 38% margin as amortization keeps falling; 22x P/E on model GAAP EPS.
  • Base case: +4.0% revenue CAGR as growth products offset denosumab erosion and Medicare prices on Enbrel (2026) and Otezla (2027); 34% margin; 18x P/E on model GAAP EPS.
  • Worst case: 0% revenue CAGR with MariTide delayed, Repatha selected for price setting from 2029, wider MFN and 340B discounts and an adverse Tax Court outcome; 28% margin; 14x P/E on model GAAP EPS.
  • Share count 546m in all cases (no buybacks in 9M 2026); interest and other expense $2.6bn a year; tax rate 15%; quarterly dividend $2.52.

Scenarios, three years forward

Table 11.2 Scenario analysis, TTM Q3 2026 to FY2029
MeasureWorst caseBase caseBest case
Revenue CAGR, 3 years (%)0.04.07.0
Revenue, FY2029 ($bn)38.943.847.7
Operating margin, FY2029 (%)28.034.038.0
Net income, FY2029 ($bn)7.010.413.2
EPS, FY2029 ($)12.9119.1224.15
Exit P/E (x)14.018.022.0
Implied price ($)181344531
Change against $476.04 (%)(62)(28)12
Implied annual return (%)(27.6)(10.3)3.7
Operating margin in the scenario and sensitivity tables is GAAP operating margin on total revenues: 32.4% TTM Q3 2026. Model EPS is GAAP based and excludes BeOne fair value changes; exit P/E multiples apply to that GAAP EPS, against a current P/E of 27.6x on TTM GAAP EPS (20.5x on TTM non GAAP EPS). Implied annual return excludes dividends (yield 2.1% at $476.04). FY2029 is three years after TTM Q3 2026.
Figure 11.2 Three year price scenarios

Sensitivity analysis

Table 11.3 Sensitivity of implied price to revenue CAGR and operating margin at 18x P/E
Revenue CAGR \ Operating margin28%31%34%36%38%
0%$232$265$298$320$341
2%$251$286$320$344$367
4%$270$307$344$369$393
6%$291$330$369$395$421
8%$312$353$394$422$449
Cells show implied share price in year 3. Current price $476.04. Blue cells sit above it, red cells below.
Table 11.4 Sensitivity of implied price to exit P/E and operating margin at 4% revenue CAGR
Exit P/E \ Operating margin28%31%34%36%38%
14x$210$239$268$287$306
16x$240$273$306$328$349
18x$270$307$344$369$393
20x$301$341$382$410$437
22x$331$376$421$451$480
Cells show implied share price in year 3. Current price $476.04. Blue cells sit above it, red cells below.

Disclaimer

This analysis is for information only and is not financial advice. It is derived from public SEC filings retrieved via sec-api.io and is not a publication of the U.S. Securities and Exchange Commission. Scenario values are model outputs under stated assumptions and are not forecasts. Data as of 5 November 2026.

Sources

All company figures are read from SEC filings retrieved through the sec-api.io MCP server. Management statements come from the 8-K Ex 99.1 releases and the Forms 10-Q and 10-K; statements marked as stated on the call come from the Q3 2026 earnings call of 3 Nov 2026.

Table A.1 Filings used, with accession numbers
FormPeriodFiledAccession number
10-QQ3 20263 Nov 20260000318154-26-000155
8-K Ex 99.1Q3 20263 Nov 20260000318154-26-000153
10-QQ2 20264 Aug 20260000318154-26-000126
8-K Ex 99.1Q2 20264 Aug 20260000318154-26-000124
10-QQ1 202630 Apr 20260000318154-26-000057
8-K Ex 99.1Q1 202630 Apr 20260000318154-26-000054
10-KFY202513 Feb 20260000318154-26-000010
8-K Ex 99.1Q4 20253 Feb 20260000318154-26-000003
10-QQ3 20254 Nov 20250000318154-25-000072
8-K Ex 99.1Q3 20254 Nov 20250000318154-25-000070
10-QQ2 20255 Aug 20250000318154-25-000056
10-QQ1 20251 May 20250000318154-25-000020
10-KFY202414 Feb 20250000318154-25-000010
8-K Ex 99.1Q4 20244 Feb 20250000318154-25-000005
10-KFY202314 Feb 20240000318154-24-000011
8-K Ex 99.1Q4 20236 Feb 20240000318154-24-000004
10-KFY20229 Feb 20230000318154-23-000017
8-K Ex 99.1Q4 202231 Jan 20230000318154-23-000011
DEF 14A2026 AGM7 Apr 20260001193125-26-145588
8-K 5.072026 AGM20 May 20260001193125-26-232786
8-K 1.05Jul 202631 Jul 20260000318154-26-000119
8-K 1.01Feb 202619 Feb 20260001193125-26-059490
Table A.2 Competitor filings used
CompanyFormFiledAccession number
AbbVie8-K30 Oct 20260001551152-26-000033
AstraZeneca6-K30 Oct 20260001654954-26-009256
Eli Lilly10-Q29 Oct 20260000059478-26-000108
Johnson & Johnson10-Q21 Oct 20260000200406-26-000197
Merck8-K4 Aug 20260001104659-26-090045
Merck8-K29 Oct 20260001104659-26-119825
Novartis6-K27 Oct 20260001114448-26-000014
Novo Nordisk6-K4 Nov 20260001628280-26-069805
Organon10-Q30 Oct 20260001821825-26-000004
Pfizer8-K3 Nov 20260000078003-26-000125
Regeneron8-K30 Oct 20260000872589-26-000032
Sanofi6-K30 Oct 20260001121404-26-000009
argenx6-K22 Oct 20260001697862-26-000034
Table B.1 Exhibits to Forms 8-K filed in the last twelve months
FiledExhibitDocumentContent
30 Jan 2026Ex 10.1Termination Agreement with Kyowa Kirin for rocatinlimabAmgen and Kyowa Kirin agreed on 30 Jan 2026 to end their 1 Jun 2021 License and Collaboration Agreement for rocatinlimab (KHK4083, AMG 451); Amgen determined to discontinue its participation; Kyowa Kirin takes sole responsibility, at its own cost, for worldwide development, manufacture, regulatory work and commercialization
3 Feb 2026Ex 99.1Q4 and FY 2025 resultsQ4 2025 total revenues $9.87bn (+9%); product sales $9.37bn (+7%) on 10% volume growth and 4% lower net selling price; FY2025 total revenues $36.75bn (+10%); 14 products above $1bn of annual sales; GAAP EPS $14.23 (+88%); non GAAP EPS $21.84 (+10%)
19 Feb 2026Ex 1.1Underwriting Agreement for $4.0bn senior notesDated 17 Feb 2026 with BofA Securities, Citigroup, J.P. Morgan and Morgan Stanley as representatives of the underwriters; Amgen receives 99.547% of principal for the 2031 notes, 99.377% for 2036, 98.866% for 2046 and 99.053% for 2056
19 Feb 2026Ex 4.2Officer's Certificate setting terms of the 2031, 2036, 2046 and 2056 notesInitial offering prices: 99.897% (2031), 99.827% (2036), 99.616% (2046) and 99.928% (2056) of principal; Interest paid semiannually on 19 Feb and 19 Aug from 19 Aug 2026; notes issued under the 22 May 2014 indenture with The Bank of New York Mellon Trust Company as trustee
19 Feb 2026Ex 5.1Latham & Watkins legal opinion on the notesOpinion dated 19 Feb 2026 that the $4.0bn of notes are duly authorized and, once issued against payment, legally valid and binding obligations of Amgen; Covers New York law and the Delaware General Corporation Law only; registration statement on Form S 3 No. 333 293477 filed 13 Feb 2026
22 Apr 2026Ex 99.1Retirement of CTO David Reese and organizational changesDavid M. Reese, EVP and Chief Technology Officer, retires effective 30 Jun 2026 after joining Amgen in 2005; he led R&D from 2018 to 2023; From 1 Jun 2026 James Bradner becomes EVP, Research and Development, AI and Data; Sean Bruich becomes SVP, Chief Technology Officer
30 Apr 2026Ex 99.1Q1 2026 resultsQ1 2026 total revenues $8.62bn (+6%); product sales $8.22bn (+4%) on 9% volume growth, 2% lower net selling price and 2% lower inventory; GAAP EPS $3.34 (+4%); non GAAP EPS $5.15 (+5%); non GAAP operating margin 45.3% (0.4 points lower); free cash flow $1.5bn vs $1.0bn
19 May 2026Ex 99.1CFO Peter Griffith retires; Thomas Dittrich returns as CFOPeter Griffith, CFO since 2020, steps down as CFO effective 31 Aug 2026 and stays as a non executive officer EVP until 31 Jan 2027; Thomas Dittrich, 62, former CFO of Galderma, Shire and Sulzer and Amgen Chief Accounting Officer from 2010 to 2014, joins 1 Jul 2026 and becomes CFO on 1 Sep 2026
19 May 2026Ex 10.1Employment Offer Agreement with Thomas DittrichBase salary CHF 1.07m with a target bonus of 100% of salary under the Global Management Incentive Plan; 2026 long term incentive target CHF 4.5m: options CHF 1.35m, RSUs CHF 900,000 and 2026 to 2028 performance units CHF 2.25m
19 May 2026Ex 10.2Expatriate Assignment Letter of Understanding for Thomas DittrichAssignment to Thousand Oaks from 1 Sep 2026, employed by Amgen International AG and seconded to Amgen Inc.; Initial phase expected to last up to 48 months; base salary CHF 1.07m; standard EVP relocation benefits plus a CHF 250,000 relocation allowance (8 K Item 5.02)
20 May 2026Item 5.07 text2026 annual meeting vote resultsAll 12 director nominees elected at the 19 May 2026 meeting; support for CEO Robert Bradway 95.0% and Greg Garland 94.8% of votes cast, the two lowest; Say on pay approved with 97.1% of votes cast (399.3m for, 12.0m against)
31 Jul 2026Item 1.05 textMaterial cybersecurity incident in third party cloud environmentsIn Jul 2026 Amgen identified unauthorized activity involving data stored in cloud environments hosted by third party providers; Some data, including proprietary data and patient protected health information, was exfiltrated; no impact found on products, manufacturing or financial reporting systems
4 Aug 2026Ex 99.1Q2 2026 resultsQ2 2026 total revenues $10.05bn (+10%); product sales $9.54bn (+9%) driven by volume; 22 products grew at least 10%; GAAP EPS $4.37 (+65%); non GAAP EPS $6.29 (+4%); non GAAP operating margin 48.4% (0.5 points lower); free cash flow $3.5bn vs $1.9bn
26 Oct 2026Ex 99.1David W. Gibbs appointed to the boardFormer Yum! Brands CEO (2020 to 2025) joins the board on 26 Oct 2026 and sits on the Audit and Compensation and Management Development committees; Board grows to 13 directors, 12 independent; standard pay of $115,000 cash retainer, $12,500 committee retainers and a $220,000 annual RSU grant, prorated (8 K Item 5.02)
3 Nov 2026Ex 99.1Q3 2026 resultsQ3 2026 total revenues $10.37bn (+8%); product sales $9.88bn (+8%) driven by volume; 17 products annualizing above $1bn; GAAP EPS $7.08 (+19%); non GAAP EPS $6.45 (+14%); GAAP operating margin 37.5% (+9.9 points); non GAAP operating margin 47.3% (+0.2 points)