Insights derived from analysing SEC filings. Independent analysis, not a publication of the SEC.
Figures are read from the Forms 10-K for FY2021 to FY2025, the Forms 10-Q for Q1 2025 to Q3 2026 (Q3 filed 3 Nov 2026), the Forms 8-K with all their exhibits, incl. the quarterly earnings releases (Ex 99.1) with their product tables and non GAAP appendices, the notes documents of Feb 2026 (Ex 1.1, 4.2, 5.1), the Kyowa Kirin termination agreement and the CFO offer letter (Ex 10.1, 10.2), the 2026 proxy statement with the Form 8-K Item 5.07 vote results, and Forms 4 for central index key 318154, together with the filings of 13 competitor and peer companies used in chapters 2 to 5. Amgen files no separate CFO commentary; the financial sections of the Q3 2026 release (Ex 99.1) are used in its place. Statements marked as stated on the call come from the Q3 2026 earnings call of 3 Nov 2026. Accession numbers appear in the Sources appendix. Share price is the trade of 5 Nov 2026.
| Product | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 | Q3 2026 | Q3 growth (%) |
|---|---|---|---|---|---|---|
| Repatha | 794 | 870 | 876 | 953 | 1,085 | 36.6 |
| Evenity | 541 | 599 | 562 | 714 | 751 | 38.8 |
| Prolia | 1,139 | 1,054 | 727 | 759 | 632 | (44.5) |
| Xgeva | 539 | 447 | 411 | 352 | 288 | (46.6) |
| Tezspire | 377 | 474 | 343 | 486 | 538 | 42.7 |
| Enbrel | 580 | 532 | 320 | 580 | 611 | 5.3 |
| Tepezza | 560 | 457 | 490 | 576 | 526 | (6.1) |
| Blincyto | 392 | 413 | 415 | 472 | 496 | 26.5 |
| Otezla | 585 | 625 | 431 | 491 | 481 | (17.8) |
| Nplate | 457 | 385 | 412 | 430 | 472 | 3.3 |
| Uplizna | 155 | 233 | 262 | 335 | 451 | 191.0 |
| Krystexxa | 320 | 435 | 255 | 400 | 419 | 30.9 |
| Imdelltra | 178 | 234 | 258 | 288 | 406 | 128.1 |
| Vectibix | 284 | 319 | 287 | 338 | 335 | 18.0 |
| Kyprolis | 359 | 351 | 330 | 314 | 330 | (8.1) |
| Pavblu | 213 | 258 | 280 | 287 | 300 | 40.8 |
| Aranesp | 357 | 333 | 311 | 352 | 329 | (7.8) |
| Neulasta | 92 | 132 | 165 | 179 | 195 | 112.0 |
| Amjevita | 154 | 174 | 173 | 155 | 191 | 24.0 |
| Mvasi | 213 | 188 | 150 | 153 | 168 | (21.1) |
| Tavneos | 107 | 152 | 119 | 150 | 105 | (1.9) |
| Ultra rare products | 200 | 157 | 98 | 149 | 110 | (45.0) |
| Lumakras | 96 | 92 | 94 | 111 | 102 | 6.3 |
| Parsabiv | 84 | 89 | 87 | 101 | 82 | (2.4) |
| Total product sales | 9,137 | 9,367 | 8,218 | 9,537 | 9,883 | 8.2 |
| Other revenues | 420 | 499 | 400 | 517 | 482 | 14.8 |
| Total revenues | 9,557 | 9,866 | 8,618 | 10,054 | 10,365 | 8.5 |
| Company and product | Period | Sales | Growth (%) | Filed detail |
|---|---|---|---|---|
| Amgen Repatha | Q3 2026 | 1,085 | +36.6 | US $666m, rest of world $419m |
| Novartis Leqvio | Q3 2026 | 506 | +63.0 | PCSK9 siRNA dosed twice a year; growth at constant currency |
| Regeneron Praluent (US) | Q3 2026 | 81 | +20.9 | PCSK9 antibody, US net sales |
| Sanofi Praluent (outside US) | Q3 2026 | EUR 156m | +20.5 | PCSK9 antibody outside the US |
| Merck Lipfendra (enlicitide) | Q2 2026 | not filed | not filed | first oral PCSK9 inhibitor, FDA approval Jul 2026 |
| Amgen Evenity | Q3 2026 | 751 | +38.8 | US $557m, rest of world $194m |
| Eli Lilly Zepbound | Q3 2026 | 5,352 | +49.2 | tirzepatide for obesity; Mounjaro $10.72bn, +64.6% |
| Novo Nordisk obesity | Q3 2026 | DKK 26.15bn | +22.0 | growth at CER; Wegovy pill DKK 5.39bn after its 5 Jan 2026 US launch |
| Amgen MariTide | Q3 2026 | no sales | n/a | Phase 3 MARITIME program; no readout dates filed |
| Company and product | Period | Sales | Growth (%) | Filed detail |
|---|---|---|---|---|
| Amgen Uplizna | Q3 2026 | 451 | +191.0 | gMG approval Dec 2025; US $352m |
| argenx Vyvgart | Q3 2026 | 1,721 | +52.7 | FcRn blocker in gMG and CIDP |
| Amgen Tezspire (US) | Q3 2026 | 538 | +42.7 | Amgen books US sales |
| AstraZeneca Tezspire | Q3 2026 | 429 | +50.0 | AstraZeneca books sales outside the US |
| Sanofi Dupixent | Q3 2026 | EUR 5.69bn | +34.8 | approved in eosinophilic esophagitis; growth at CER |
| Amgen Enbrel | Q3 2026 | 611 | +5.3 | net selling price 14% lower under the Medicare Part D price |
| Amgen Otezla | Q3 2026 | 481 | (17.8) | rest of world (53%) after European generics; Medicare price from Jan 2027 |
| AbbVie immunology | Q3 2026 | 9,165 | +16.3 | Skyrizi, Rinvoq and Humira |
| Novartis Cosentyx | Q3 2026 | 1,857 | +9.0 | growth at constant currency |
| Amgen Tepezza | Q3 2026 | 526 | (6.1) | thyroid eye disease; US $441m |
| Amgen Krystexxa | Q3 2026 | 419 | +30.9 | uncontrolled gout; US only |
| Company and product | Period | Sales | Growth (%) | Filed detail |
|---|---|---|---|---|
| Amgen Prolia | Q3 2026 | 632 | (44.5) | US RANKL antibody patents expired Feb 2025 |
| Amgen Xgeva | Q3 2026 | 288 | (46.6) | same molecule (denosumab), oncology use |
| Organon Bildyos and Bilprevda | Q3 2026 | 24 | n/m | denosumab biosimilars launched in Q3 2025; Q3 2025 $3m; $60m in 9M 2026 |
| Amgen Pavblu | Q3 2026 | 300 | +40.8 | aflibercept biosimilar; US $294m |
| Regeneron EYLEA and EYLEA HD (US) | Q3 2026 | 1,099 | (1.2) | reference product for Pavblu; EYLEA 2 mg $400m, (41.3%) |
| Amgen Blincyto | Q3 2026 | 496 | +26.5 | BiTE in B cell leukemia; rest of world $227m |
| Amgen Imdelltra | Q3 2026 | 406 | +128.1 | BiTE in small cell lung cancer; rest of world $182m |
| AstraZeneca Imfinzi | Q3 2026 | 1,990 | +24.0 | partner drug in DeLLphi 305 |
| Merck Keytruda family | Q3 2026 | 8,601 | +5.6 | reference product for ABP 234 |
| J&J oncology | Sep 2026 quarter | 7,602 | +16.4 | quarter to 27 Sep 2026 |
| Pfizer oncology | Q3 2026 | 4,327 | +9.9 | 2026 portfolio definition |
| Line item | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM Q3 2026 |
|---|---|---|---|---|---|---|
| Revenue | 26.0 | 26.3 | 28.2 | 33.4 | 36.8 | 38.9 |
| Gross profit | 19.5 | 19.9 | 19.7 | 20.6 | 24.7 | 27.6 |
| Research and development | 4.8 | 4.4 | 4.8 | 6.0 | 7.3 | 7.8 |
| Selling, general and administrative | 5.4 | 5.4 | 6.2 | 7.1 | 7.1 | 7.0 |
| Operating income | 7.6 | 9.6 | 7.9 | 7.3 | 9.1 | 12.6 |
| Net income | 5.9 | 6.6 | 6.7 | 4.1 | 7.7 | 9.4 |
| Diluted EPS ($) | 10.28 | 12.11 | 12.49 | 7.56 | 14.23 | 17.24 |
| Operating cash flow | 9.3 | 9.7 | 8.5 | 11.5 | 10.0 | 12.0 |
| Capital expenditure | (0.9) | (0.9) | (1.1) | (1.1) | (1.9) | (2.5) |
| Free cash flow | 8.4 | 8.8 | 7.4 | 10.4 | 8.1 | 9.6 |
| Stock based compensation | 0.3 | 0.4 | 0.4 | 0.5 | 0.5 | 0.5 |
| Cash and investments | 8.0 | 9.3 | 10.9 | 12.0 | 9.1 | 13.2 |
| Total debt | 33.3 | 38.9 | 64.6 | 60.1 | 54.6 | 54.0 |
| Total equity | 6.7 | 3.7 | 6.2 | 5.9 | 8.7 | 14.4 |
| Metric | Q3 2025 | Q3 2026 | Change |
|---|---|---|---|
| Revenue ($bn) | 9.56 | 10.37 | 8.5% |
| Gross profit ($bn) | 6.48 | 7.58 | 17.0% |
| Operating income ($bn) | 2.53 | 3.71 | 46.9% |
| Net income ($bn) | 3.22 | 3.86 | 20.1% |
| Diluted EPS ($) | 5.93 | 7.08 | 19.4% |
| Operating cash flow ($bn) | 4.68 | 4.24 | (9.5%) |
| Free cash flow ($bn) | 4.25 | 3.65 | (14.0%) |
| Operating margin (%) | 26.4 | 35.8 | 9.4 pts |
| Net margin (%) | 33.7 | 37.3 | 3.6 pts |
| Ratio | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM Q3 2026 |
|---|---|---|---|---|---|---|
| Growth and margins | ||||||
| Revenue growth (%) | n/a | 1.3 | 7.1 | 18.6 | 10.0 | n/a |
| Gross margin (%) | 75.2 | 75.7 | 70.0 | 61.5 | 67.2 | 70.9 |
| Operating margin (%) | 29.4 | 36.3 | 28.0 | 21.7 | 24.7 | 32.4 |
| Net margin (%) | 22.7 | 24.9 | 23.8 | 12.2 | 21.0 | 24.1 |
| FCF margin (%) | 32.3 | 33.4 | 26.1 | 31.1 | 22.0 | 24.6 |
| Cost and investment intensity | ||||||
| R&D (%) revenue | 18.5 | 16.8 | 17.0 | 17.8 | 19.8 | 20.2 |
| SBC (%) revenue | 1.3 | 1.5 | 1.5 | 1.6 | 1.3 | 1.3 |
| Capex (%) revenue | 3.4 | 3.6 | 3.9 | 3.3 | 5.1 | 6.3 |
| Effective tax rate (%) | 12.1 | 10.8 | 14.5 | 11.3 | 14.1 | 15.0 |
| Returns | ||||||
| ROE (%) | 88.0 | 126.5 | 135.8 | 67.6 | 106.1 | 65.4 |
| ROA (%) | 9.6 | 10.4 | 8.3 | 4.3 | 8.5 | 9.8 |
| ROIC (%) | 21.0 | 25.6 | 11.3 | 11.9 | 14.4 | 19.4 |
| Asset turnover (x) | 0.42 | 0.40 | 0.29 | 0.36 | 0.41 | 0.41 |
| Liquidity and leverage | ||||||
| Current ratio (x) | 1.59 | 1.41 | 1.65 | 1.26 | 1.14 | 1.48 |
| Debt to equity (x) | 4.97 | 10.64 | 10.37 | 10.23 | 6.31 | 3.76 |
| Net cash ($bn) | (25.3) | (29.6) | (53.7) | (48.1) | (45.5) | (40.8) |
| Efficiency and cash quality | ||||||
| Days sales outstanding | 69 | 77 | 94 | 74 | 95 | 97 |
| Inventory days | 231 | 281 | 411 | 199 | 189 | 206 |
| FCF to net income (x) | 1.42 | 1.34 | 1.10 | 2.54 | 1.05 | 1.02 |
| Shareholder returns (%) FCF | 107 | 120 | 62 | 48 | 63 | 56 |
| Measure | Value |
|---|---|
| Market cap ($bn) | 257.5 |
| Enterprise value (net debt at 30 Sep 2026) ($bn) | 298.3 |
| P/E on TTM Q3 2026 GAAP EPS (x) | 27.6 |
| P/E on TTM non GAAP EPS (x) | 20.5 |
| P/E on FY2026 non GAAP EPS guidance midpoint (x) | 20.4 |
| EV/Sales TTM Q3 2026 (x) | 7.7 |
| FCF yield on TTM FCF (%) | 3.7 |
| Price/Book at 30 Sep 2026 (x) | 17.9 |
| Dividend yield (%) | 2.1 |
| Line | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 | Q3 2026 |
|---|---|---|---|---|---|
| Cost of sales (% of revenues) | 32.2 | 30.2 | 31.8 | 28.0 | 26.9 |
| Research and development (% of revenues) | 19.9 | 21.7 | 19.9 | 18.6 | 20.4 |
| Selling, general and administrative (% of revenues) | 18.0 | 19.8 | 18.6 | 17.4 | 16.2 |
| Other operating expenses (% of revenues) | 3.4 | 0.8 | (1.3) | 1.2 | 0.7 |
| Operating income (% of revenues) | 26.4 | 27.6 | 30.9 | 35.0 | 35.8 |
| Net income (% of revenues) | 33.7 | 13.5 | 21.1 | 23.6 | 37.3 |
| Product | FY2023 (from 6 Oct) | FY2024 | FY2025 | 9M 2026 |
|---|---|---|---|---|
| Tepezza | 448 | 1,851 | 1,903 | 1,592 |
| Krystexxa | 272 | 1,185 | 1,340 | 1,074 |
| Uplizna | 65 | 379 | 655 | 1,048 |
| Ultra rare products | 164 | 758 | 719 | 357 |
| Total, four lines | 949 | 4,173 | 4,617 | 4,071 |
| Year | Principal |
|---|---|
| 2026 | 4,571 |
| 2027 | 2,724 |
| 2028 | 4,984 |
| 2029 | 2,943 |
| 2030 | 4,000 |
| thereafter | 36,822 |
| Total principal | 56,044 |
| Item | Outlook | Source |
|---|---|---|
| FY2026 total revenues | $38.9bn to $39.7bn (Aug: $38.2bn to $39.4bn; Feb: $37.0bn to $38.4bn) | 8-K Ex 99.1, 3 Nov 2026 |
| FY2026 EPS | GAAP $18.34 to $19.28; non GAAP $22.90 to $23.70 (Aug: $22.30 to $23.50) | 8-K Ex 99.1, 3 Nov 2026 |
| FY2026 tax rate | GAAP 14.5% to 16.0%; non GAAP 15.0% to 16.5% | 8-K Ex 99.1, 3 Nov 2026 |
| Capex and buybacks | capex about $2.6bn; repurchases not to exceed $3.0bn (none in 9M 2026) | 8-K Ex 99.1, 3 Nov 2026; 10-Q Q3 2026 |
| Non GAAP operating margin and other revenues | about 45% to 46% of product sales; other revenues about $1.9bn | Stated on the Q3 2026 call |
| Product outlook | Prolia and Xgeva: further erosion from biosimilars in 2026; Otezla: lower net price from Medicare price setting from 2027; Repatha: net price lower by about mid single digits in 2026 | 10-Q Q3 2026 MD&A; 8-K Ex 99.1, 3 Feb 2026 |
| Speaker | Date and source | Statement |
|---|---|---|
| Robert A. Bradway, Chairman and CEO | 3 Nov 2026, 8-K Ex 99.1 | “deliver durable growth well into the next decade” |
| Robert A. Bradway, Chairman and CEO | 4 Aug 2026, 8-K Ex 99.1 | “Our six key growth drivers grew 26% year over year” |
| Robert A. Bradway, Chairman and CEO | 30 Apr 2026, 8-K Ex 99.1 | “enabling us to grow through expected patent expirations and increased competition” |
| Item | Disclosure |
|---|---|
| 10-K FY2025, customers | McKesson, Cencora and Cardinal Health each above 10% of revenues; together 77% of worldwide gross revenues in 2025 (77% in 2024, 79% in 2023). |
| 10-K FY2025, Horizon | Acquired 6 Oct 2023 for $27.8bn ($116.50 per share); developed product technology rights $19.6bn amortized over about 10 years and IPR&D $1.06bn ($20.7bn together); acquired inventory at fair value $5.0bn; goodwill $3.1bn. |
| 10-K FY2025, Otezla | Intangible impairments of $1.2bn in 2025 after Otezla was selected for Medicare price setting. |
| 10-K FY2025 and 10-Q Q3 2026, IRS dispute | US against Puerto Rico profit allocation: 2010 to 2012 about $3.6bn tax plus interest; 2013 to 2015 about $5.1bn plus interest and $2.0bn of penalties, before offsets of up to $0.9bn and $2.2bn of repatriation tax paid; Tax Court decision expected no earlier than late 2026 or early 2027; similar draft NOPAs for 2016 to 2018 (Apr to Sep 2026). |
| 10-Q Q3 2026, BeOne | Stake of about 17% at fair value $6.9bn; Q3 2026 unrealized gain $1.5bn; letter agreement with BeOne Medicines of 10 Jul 2026 filed as Ex 10.20.8. |
| 10-Q Q3 2026, legal | Prolia and Xgeva BPCIA suits against Amneal, Dr. Reddy's and Alkem continue (new patent asserted Oct 2026); Regeneron Pavblu patent suits, claim construction 1 Dec 2026; BMS and Ono sued on 8 Sep 2026 over ABP 206; securities class action settlement preliminarily approved 21 Oct 2026. |
| 10-Q Q3 2026, tariffs | Section 232 tariffs on patented pharmaceuticals proclaimed Apr 2026; Amgen has about three years of relief from Dec 2025 tied to US manufacturing investment in Ohio, North Carolina and Puerto Rico. |
| 10-Q Q3 2026, liquidity | 9M 2026 operating cash flow $10.43bn (9M 2025 included the final $1.8bn repatriation tax payment); capex $1.81bn; dividends $4.08bn; $4.0bn revolver extended to Mar 2029, undrawn. |
| Measure | 3 Feb 2026 | 30 Apr 2026 | 4 Aug 2026 | 3 Nov 2026 |
|---|---|---|---|---|
| Total revenues ($bn) | 37.0 to 38.4 | 37.1 to 38.5 | 38.2 to 39.4 | 38.9 to 39.7 |
| Non GAAP diluted EPS ($) | 21.60 to 23.00 | 21.70 to 23.10 | 22.30 to 23.50 | 22.90 to 23.70 |
| Company | Revenue TTM ($bn) | Revenue growth (%) | Gross margin (%) | Operating margin (%) | Net margin (%) | FCF margin (%) | ROE (%) | Net cash ($bn) | Market value ($bn) | EV/Sales (x) | P/E TTM (x) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AMGN | 38.9 | 8.2 | 70.9 | 32.4 | 24.1 | 24.6 | 78.4 | (40.8) | 258 | 7.7 | 27.6 |
| REGN | 16.9 | 36.3 | 85.8 | 28.8 | 28.5 | 22.6 | 14.9 | 16.2 | 98 | 4.8 | 20.8 |
| GILD | 31.0 | 6.5 | 79.9 | (7.6) | (12.5) | 44.5 | n/a | (19.8) | 212 | 7.5 | n/a |
| LLY | 86.5 | 45.5 | 83.6 | 40.3 | 31.9 | 22.7 | 82.6 | (44.6) | 1,331 | 15.9 | 45.9 |
| ABBV | 66.0 | 10.3 | 73.7 | 32.2 | 15.7 | 28.3 | n/a | (64.3) | 505 | 8.6 | 49.2 |
| BMY | 50.0 | 5.2 | 69.2 | 23.1 | 18.5 | 18.6 | 44.1 | (29.9) | 128 | 3.2 | 13.8 |
| Date | Items | Event |
|---|---|---|
| 4 Nov 2025 | 2.02, 9.01 | Q3 2025 results: revenues $9.6bn (+12%), GAAP EPS $5.93, non GAAP EPS $5.64; FY2025 revenue guidance raised to $35.8bn to $36.6bn. Ex 99.1. |
| 30 Jan 2026 | 1.02, 9.01 | Termination agreement with Kyowa Kirin ending the 1 Jun 2021 licence and collaboration agreement for rocatinlimab; effective on regulatory approval. Ex 10.1. |
| 3 Feb 2026 | 2.02, 9.01 | Q4 and FY2025 results: FY2025 revenues $36.75bn (+10%), GAAP EPS $14.23, non GAAP EPS $21.84, free cash flow $8.1bn; FY2026 guidance revenues $37.0bn to $38.4bn, non GAAP EPS $21.60 to $23.00. Ex 99.1. |
| 19 Feb 2026 | 1.01, 9.01 | $4.0bn of senior notes due 2031, 2036, 2046 and 2056 at 4.20% to 5.65%; net proceeds about $3.96bn. Ex 1.1 underwriting agreement, Ex 4.2 officer's certificate, Ex 5.1 legal opinion. |
| 22 Apr 2026 | 5.02, 9.01 | EVP and CTO David Reese to retire on 30 Jun 2026; his responsibilities move to James Bradner (R&D, AI and Data), Murdo Gordon (Global Markets and Policy) and Peter Griffith from 1 Jun 2026. Ex 99.1. |
| 30 Apr 2026 | 2.02, 9.01 | Q1 2026 results: revenues $8.62bn (+6%), GAAP EPS $3.34, non GAAP EPS $5.15; FY2026 revenue guidance $37.1bn to $38.5bn. Ex 99.1. |
| 19 May 2026 | 5.02, 9.01 | CFO Peter Griffith steps down as CFO on 31 Aug 2026 and retires on 31 Jan 2027; Thomas Dittrich EVP and CFO from 1 Sep 2026. Ex 99.1 release, Ex 10.1 offer agreement, Ex 10.2 expatriate assignment letter. |
| 20 May 2026 | 5.07 | Annual meeting of 19 May 2026: 12 directors elected, say on pay approved, Ernst & Young ratified, independent chair proposal rejected. |
| 31 Jul 2026 | 1.05 | Material cybersecurity incident: unauthorized activity in third party cloud environments identified in Jul 2026; proprietary data and patient protected health information exfiltrated; deemed material on 29 Jul 2026; not reasonably likely to have a material financial impact as of filing. |
| 4 Aug 2026 | 2.02, 9.01 | Q2 2026 results: revenues $10.05bn (+10%), GAAP EPS $4.37, non GAAP EPS $6.29; FY2026 revenue guidance $38.2bn to $39.4bn. Ex 99.1. |
| 26 Oct 2026 | 5.02, 9.01 | David W. Gibbs, CEO of Yum! Brands from 2020 to 2025, appointed director; board at 13 members, 12 independent. Ex 99.1. |
| 3 Nov 2026 | 2.02, 9.01 | Q3 2026 results: revenues $10.37bn (+8%), GAAP EPS $7.08, non GAAP EPS $6.45, free cash flow $3.7bn; FY2026 revenue guidance $38.9bn to $39.7bn. Ex 99.1. |
| Contract | Terms |
|---|---|
| Senior notes, Feb 2026 (Ex 1.1, 4.2, 5.1) | $4.0bn: $1.0bn 4.200% due 2031, $1.75bn 4.850% due 2036, $500m 5.500% due 2046, $750m 5.650% due 2056; underwriters BofA Securities, Citigroup, J.P. Morgan and Morgan Stanley; issued under the 22 May 2014 indenture with The Bank of New York Mellon Trust Company; repurchase at 101% on a change of control triggering event; net proceeds about $3.96bn. |
| Kyowa Kirin termination agreement (Ex 10.1, 30 Jan 2026) | Ends the 1 Jun 2021 licence and collaboration agreement for rocatinlimab; Kyowa Kirin takes sole responsibility, at its own cost, for worldwide development, manufacture and commercialization; effective after HSR waiting periods; outside date 1 Apr 2026, extendable for a government shutdown to no later than 1 Jun 2026 unless both parties agree. |
| CFO offer agreement (Ex 10.1, 10.2, 19 May 2026) | Thomas Dittrich: base salary CHF 1.07m, target bonus 100% of salary; 2026 long term incentive CHF 4.5m; one time RSU award CHF 4.7m and cash bonus CHF 4.0m for forgone Galderma pay; two year retention bonus CHF 5.8m; relocation allowance CHF 250,000; employed first by Amgen (Europe) GmbH in Switzerland, with employment moving to Amgen International AG on relocation to Thousand Oaks under the expatriate assignment letter. |
| Horizon acquisition (6 Oct 2023) | $27.8bn consideration ($116.50 per share), $26.7bn in cash, funded mainly with $27.78bn of long term debt issued in FY2023; the $1.8bn term loan was repaid in full in 9M 2026. |
| Revolving credit facility and swaps | $4.0bn unsecured revolver extended to Mar 2029, undrawn at 30 Sep 2026; interest rate swaps of $6.7bn notional (fixed to SOFR) and cross currency swaps of $2.7bn notional (10-K FY2025). |
| BeOne Medicines letter agreement (10-Q Q3 2026, Ex 10.20.8) | Dated 10 Jul 2026 and filed with the Q3 2026 Form 10-Q; Amgen holds about 17% of BeOne at a fair value of $6.9bn. |
| Proposal | For (bn votes) | Against (bn votes) | Abstain (bn votes) | For as % of votes cast | Result |
|---|---|---|---|---|---|
| Director: Robert A. Bradway | 0.390 | 0.020 | 0.002 | 95.0 | Elected |
| Director: Greg C. Garland | 0.391 | 0.021 | 0.001 | 94.8 | Elected |
| Director: Robert A. Eckert | 0.393 | 0.019 | 0.001 | 95.3 | Elected |
| Advisory vote on executive compensation | 0.399 | 0.012 | 0.002 | 97.1 | Approved |
| Ratify Ernst & Young as auditor for FY2026 | 0.448 | 0.028 | 0.001 | 94.1 | Approved |
| Shareholder: independent board chair | 0.073 | 0.338 | 0.002 | 17.7 | Not approved |
| Holder | Shares (m) | Share of class (%) | Source |
|---|---|---|---|
| BlackRock, Inc. | 40.8 | 7.6 | 2026 proxy (Schedule 13G/A of 17 Apr 2025) |
| State Street Corporation | 29.5 | 5.5 | 2026 proxy (Schedule 13G/A of 30 Jan 2024) |
| Insider | Role | Date | Type | Shares and price | Value ($m) |
|---|---|---|---|---|---|
| Esteban Santos | EVP Operations | 26 Feb 2026 | Option exercise and sale | 54,792 at $379.12 | 20.8 |
| Murdo Gordon | EVP | 12 Nov 2025 | Sale | 6,879 at $336.83 | 2.3 |
| Nancy Grygiel | SVP | 6 Aug 2026 | Option exercise and sale | 2,970 at $402.16 | 1.2 |
| Derek Miller | SVP Human Resources | 6 Aug 2026 | Option exercise and sale | 3,890 at $402.54 | 1.6 |
| Rachna Khosla | SVP Business Development | 11 to 13 Aug 2026 | Sale | 3,252 at $412.57 to $416.43 | about 1.3 |
| Robert A. Bradway | Chairman and CEO | 4 Mar 2026 | Option exercise | 119,782 at $156.35; 84,285 withheld at $379.27 | not open market |
| Risk | Disclosure and change |
|---|---|
| Medicare price setting | Enbrel Part D price since 1 Jan 2026 (net selling price 19% lower in 9M 2026); Otezla from Jan 2027; Repatha may face price setting as early as Jan 2029 (10-Q Q3 2026). CMS sets prices for 10 drugs from 2026, 15 more in each of 2027 and 2028 and 20 a year from 2029. Repatha Q3 2026 sales $1.09bn. |
| Medicaid, 340B and state actions | CMS GENEROUS Medicaid rebate model (all 50 states applied, Sep 2026); HRSA 340B rebate pilot for Enbrel and Otezla from Jan 2027; Colorado upper payment limit on Enbrel preliminarily enjoined; Washington PDAB selected Otezla on 16 Sep 2026; Colorado drug importation authorized Jun 2026. |
| Tavneos approval | FDA asked for a voluntary US withdrawal on 16 Jan 2026; CDER proposed withdrawal on 27 Apr 2026; Amgen requested a hearing on 1 Jun 2026 and filed materials on 23 Jul 2026, which await CDER; the European Commission revoked the EU authorization in Aug 2026. Sales $459m in FY2025 and $105m in Q3 2026; the product stays on the US market during the process. |
| Biosimilar competition | US RANKL antibody patents expired Feb 2025 and select European patents Nov 2025; Prolia plus Xgeva $920m in Q3 2026 against $1.68bn; BPCIA suits against Amneal, Dr. Reddy's and Alkem continue. |
| IRS tax dispute | About $8.7bn of tax plus interest and $2.0bn of penalties claimed for 2010 to 2015, before offsets of up to $3.1bn of repatriation tax paid; Tax Court decision expected no earlier than late 2026 or early 2027; similar draft NOPAs for 2016 to 2018. |
| Cybersecurity | Item 1.05 incident (31 Jul 2026): proprietary data and patient protected health information exfiltrated from third party cloud environments; no effect found on products, manufacturing or financial reporting systems; the cyber factor now names AI orchestrated attacks. |
| Manufacturing and supply | Concentration of manufacturing in Puerto Rico with grid instability; Krystexxa drug substance made by a contract manufacturer in Israel affected by the conflict with Iran; Jun 2026 recalls of Kyprolis lots (Turkey) and Corlanor and Sensipar lots (US) (10-Q Q2 2026). |
| Customer concentration | Three US wholesalers accounted for 77% of worldwide gross revenues in 2025. |
| Measure | 10-K FY2024 | 10-K FY2025 |
|---|---|---|
| Risk factors (count) | 28 | 28 |
| Words in Item 1A | 22,916 | 22,258 |
| Change | Risk factor | What changed |
|---|---|---|
| Reworded | Coverage, reimbursement and pricing pressure | Adds the 4 Jul 2025 OB3 law and its Medicare, Medicaid and ACA changes, the 12 May 2025 MFN executive order and the 31 Jul 2025 MFN letter sent to Amgen; drops the sentence on budget pressure from the economic downturn and inflation; body grows from 417 to 531 words |
| Reworded | US federal coverage and reimbursement policies | States CMS has set Medicare Part D prices for Enbrel (from Jan 2026) and Otezla (from Jan 2027), that CMS may reset prices, and that Amgen announced in Dec 2025 actions satisfying the July MFN letter and an expanded direct to patient program; adds the 15 Apr 2025 executive order on small molecule and biologic treatment and CBO projections of OB3 Medicaid cuts |
| Reworded | State pricing actions and 340B | Adds Colorado PDAB's Oct 2025 upper payment limit on Enbrel, effective no earlier than 1 Jan 2027, and Washington PDAB's 16 Jul 2025 selection of Enbrel; the named list of states with 340B contract pharmacy laws expands, states introducing such bills rise from 25 to 30, and FDA steps to ease state drug importation are added |
| Reworded | US commercial payer actions | Removes the Repatha access and rebate history, the Tezspire Medicare contractor exclusion example and the FTC statistic that six integrated plans controlled about 94% of prescriptions; body shrinks from 763 to 414 words and cross refers to the wholesaler and PBM concentration factor |
| Reworded | Tax liabilities, IRS dispute, OECD and OB3 | Heading now names OB3; adds Tax Court milestones (post trial briefs 13 Jun 2025, oral argument 16 Jul 2025, reply briefs 10 Oct 2025), an IRS audit of 2019 to 2022 expected to begin in H1 2026, and OECD guidance of 5 Jan 2026 exempting US companies from extraterritorial minimum taxes from 1 Jan 2026 |
| Reworded | Acquisitions and integration | Drops the Horizon integration and rare disease commercialization passage; states rating agencies downgraded Amgen after the Horizon debt and that Amgen has substantially returned to its pre acquisition capital structure; body shrinks from 759 to 563 words |
| Reworded | IT breakdown, cyberattack or security breach | Adds AI enabled tools and AI orchestrated attacks, citing a documented case of an AI agent running a large intrusion campaign, reliance on third parties for identity and access management, and a Nov 2025 third party incident; replaces named past incidents (Okta 2022, a vendor breach covering 1.7m patients) with general wording and adds state AI laws |
| Reworded | Doing business internationally | Heading adds new markets; adds the BIOSECURE Act signed in Dec 2025, tariffs that raised production costs to a limited degree in 2025, and the effect of non US prices on MFN calculations |
| Reworded | Access to capital and credit markets | Removes the reference to debt raised for the 2023 Horizon acquisition limiting financing; states Amgen expects to access capital markets from time to time; body shrinks from 335 to 232 words |
| Reworded | Biosimilar and generic competition | Adds FDA and EMA support for streamlined biosimilar approval without routine comparative efficacy studies and EU interchangeability clarity; removes detailed US history (first interchangeable 2021, Jun 2024 draft guidance, umbrella exclusivity, USMCA data exclusivity); body shrinks from 1,381 to 1,033 words |
| Reworded | Puerto Rico manufacturing concentration | Replaces the dated list of Hurricanes Maria (2017) and Fiona (2022), the 2020 earthquakes, the 31 Dec 2024 island outage and COVID lockdowns with general wording on grid instability and reliance on own power generation; body halves from 702 to 354 words |
| Reworded | Sustainability objectives | Heading changes from 'environmental, social and governance objectives' to 'sustainability objectives'; removes the figure of at least 16 states with laws barring ESG factors in pension investing |
| Reworded | Global economic conditions | Adds the 2 Apr 2025 tariff order (10% universal tariff, higher rates on about 60 countries, pharmaceuticals partly exempt), the 24 Oct 2025 Section 301 investigation of China and tariffs that raised costs to a limited extent; removes COVID recession, debt ceiling and Ukraine inflation passages |
| Filing | Change disclosed |
|---|---|
| 10-Q Q1 2026, filed 30 Apr 2026 | Restates the pricing, international, cyber, regulatory approval and global economy factors with updates: the Administration's call for Congress to codify MFN terms, Enbrel price setting already cutting profitability and PBM reform; Tavneos added to the regulatory approval factor (FDA request of 16 Jan 2026 to withdraw, Amgen refusal 28 Jan 2026, drug safety communication 31 Mar 2026, CDER withdrawal proposal 27 Apr 2026); Middle East conflict effects on shipping, airspace and energy, and nation state cyber threats and AI tool reliability |
| 10-Q Q2 2026, filed 4 Aug 2026 | Adds the CMS GENEROUS Medicaid rebate model, the preliminary injunction on Colorado's Enbrel price limit and FDA authorization of Colorado drug importation (Jun 2026); the cyber factor cites the cloud data theft disclosed in the 31 Jul 2026 8-K; the manufacturing factor adds the Krystexxa drug substance CMO in Israel affected by the conflict with Iran and Jun 2026 recalls of Kyprolis lots (Turkey) and Corlanor and Sensipar lots (US) |
| 10-Q Q3 2026, filed 3 Nov 2026 | Updates only the pricing and regulatory approval factors: Repatha may face Medicare price setting as early as Jan 2029, Washington PDAB selected Otezla on 16 Sep 2026, HRSA approved a 340B rebate pilot for Enbrel and Otezla from Jan 2027, 23 states have 340B mandate laws; Tavneos: Amgen's 23 Jul 2026 submission awaits CDER and the European Commission revoked the EU authorization in Aug 2026 |
| Factor | Current value | Best case requires | Evidence in filings and calls |
|---|---|---|---|
| MariTide Phase 3 outcome and timing | MARITIME 1 and 2 ongoing; CV and both sleep apnea studies fully enrolled; no readout date filed | weight loss competitive with tirzepatide and approval of monthly or less frequent dosing by 2028 or 2029 | 8-K Ex 99.1 of 3 Nov 2026; 10-K FY2025 Phase 2 Part 2 data |
| Repatha growth | Q3 2026 $1.09bn, +37%; 9M 2026 $2.91bn | VESALIUS CV label expansion adds US volume; no Medicare selection for 2029 | 10-Q Q3 2026; EU approval Aug 2026 |
| Denosumab erosion | Prolia plus Xgeva Q3 2026 $920m against $1.68bn | decline flattens by 2027 | 10-Q Q3 2026 MD&A |
| Price setting and MFN | Enbrel net selling price (19%) in 9M 2026; Otezla from 2027 | no further Amgen products selected before 2029; limited MFN effect | 10-Q Q3 2026 risk factors |
| Rare disease and oncology launches | Uplizna $451m (+191%), Imdelltra $406m (+128%), Tezspire $538m (+43%) | each above $2bn of annual sales | 8-K Ex 99.1 of 3 Nov 2026 |
| Debt and tax case | net debt $40.8bn; IRS claims pending | favourable Tax Court ruling; debt below $45bn | 10-Q Q3 2026 |
| Measure | Worst case | Base case | Best case |
|---|---|---|---|
| Revenue CAGR, 3 years (%) | 0.0 | 4.0 | 7.0 |
| Revenue, FY2029 ($bn) | 38.9 | 43.8 | 47.7 |
| Operating margin, FY2029 (%) | 28.0 | 34.0 | 38.0 |
| Net income, FY2029 ($bn) | 7.0 | 10.4 | 13.2 |
| EPS, FY2029 ($) | 12.91 | 19.12 | 24.15 |
| Exit P/E (x) | 14.0 | 18.0 | 22.0 |
| Implied price ($) | 181 | 344 | 531 |
| Change against $476.04 (%) | (62) | (28) | 12 |
| Implied annual return (%) | (27.6) | (10.3) | 3.7 |
| Revenue CAGR \ Operating margin | 28% | 31% | 34% | 36% | 38% |
|---|---|---|---|---|---|
| 0% | $232 | $265 | $298 | $320 | $341 |
| 2% | $251 | $286 | $320 | $344 | $367 |
| 4% | $270 | $307 | $344 | $369 | $393 |
| 6% | $291 | $330 | $369 | $395 | $421 |
| 8% | $312 | $353 | $394 | $422 | $449 |
| Exit P/E \ Operating margin | 28% | 31% | 34% | 36% | 38% |
|---|---|---|---|---|---|
| 14x | $210 | $239 | $268 | $287 | $306 |
| 16x | $240 | $273 | $306 | $328 | $349 |
| 18x | $270 | $307 | $344 | $369 | $393 |
| 20x | $301 | $341 | $382 | $410 | $437 |
| 22x | $331 | $376 | $421 | $451 | $480 |
This analysis is for information only and is not financial advice. It is derived from public SEC filings retrieved via sec-api.io and is not a publication of the U.S. Securities and Exchange Commission. Scenario values are model outputs under stated assumptions and are not forecasts. Data as of 5 November 2026.
All company figures are read from SEC filings retrieved through the sec-api.io MCP server. Management statements come from the 8-K Ex 99.1 releases and the Forms 10-Q and 10-K; statements marked as stated on the call come from the Q3 2026 earnings call of 3 Nov 2026.
| Form | Period | Filed | Accession number |
|---|---|---|---|
| 10-Q | Q3 2026 | 3 Nov 2026 | 0000318154-26-000155 |
| 8-K Ex 99.1 | Q3 2026 | 3 Nov 2026 | 0000318154-26-000153 |
| 10-Q | Q2 2026 | 4 Aug 2026 | 0000318154-26-000126 |
| 8-K Ex 99.1 | Q2 2026 | 4 Aug 2026 | 0000318154-26-000124 |
| 10-Q | Q1 2026 | 30 Apr 2026 | 0000318154-26-000057 |
| 8-K Ex 99.1 | Q1 2026 | 30 Apr 2026 | 0000318154-26-000054 |
| 10-K | FY2025 | 13 Feb 2026 | 0000318154-26-000010 |
| 8-K Ex 99.1 | Q4 2025 | 3 Feb 2026 | 0000318154-26-000003 |
| 10-Q | Q3 2025 | 4 Nov 2025 | 0000318154-25-000072 |
| 8-K Ex 99.1 | Q3 2025 | 4 Nov 2025 | 0000318154-25-000070 |
| 10-Q | Q2 2025 | 5 Aug 2025 | 0000318154-25-000056 |
| 10-Q | Q1 2025 | 1 May 2025 | 0000318154-25-000020 |
| 10-K | FY2024 | 14 Feb 2025 | 0000318154-25-000010 |
| 8-K Ex 99.1 | Q4 2024 | 4 Feb 2025 | 0000318154-25-000005 |
| 10-K | FY2023 | 14 Feb 2024 | 0000318154-24-000011 |
| 8-K Ex 99.1 | Q4 2023 | 6 Feb 2024 | 0000318154-24-000004 |
| 10-K | FY2022 | 9 Feb 2023 | 0000318154-23-000017 |
| 8-K Ex 99.1 | Q4 2022 | 31 Jan 2023 | 0000318154-23-000011 |
| DEF 14A | 2026 AGM | 7 Apr 2026 | 0001193125-26-145588 |
| 8-K 5.07 | 2026 AGM | 20 May 2026 | 0001193125-26-232786 |
| 8-K 1.05 | Jul 2026 | 31 Jul 2026 | 0000318154-26-000119 |
| 8-K 1.01 | Feb 2026 | 19 Feb 2026 | 0001193125-26-059490 |
| Company | Form | Filed | Accession number |
|---|---|---|---|
| AbbVie | 8-K | 30 Oct 2026 | 0001551152-26-000033 |
| AstraZeneca | 6-K | 30 Oct 2026 | 0001654954-26-009256 |
| Eli Lilly | 10-Q | 29 Oct 2026 | 0000059478-26-000108 |
| Johnson & Johnson | 10-Q | 21 Oct 2026 | 0000200406-26-000197 |
| Merck | 8-K | 4 Aug 2026 | 0001104659-26-090045 |
| Merck | 8-K | 29 Oct 2026 | 0001104659-26-119825 |
| Novartis | 6-K | 27 Oct 2026 | 0001114448-26-000014 |
| Novo Nordisk | 6-K | 4 Nov 2026 | 0001628280-26-069805 |
| Organon | 10-Q | 30 Oct 2026 | 0001821825-26-000004 |
| Pfizer | 8-K | 3 Nov 2026 | 0000078003-26-000125 |
| Regeneron | 8-K | 30 Oct 2026 | 0000872589-26-000032 |
| Sanofi | 6-K | 30 Oct 2026 | 0001121404-26-000009 |
| argenx | 6-K | 22 Oct 2026 | 0001697862-26-000034 |
| Filed | Exhibit | Document | Content |
|---|---|---|---|
| 30 Jan 2026 | Ex 10.1 | Termination Agreement with Kyowa Kirin for rocatinlimab | Amgen and Kyowa Kirin agreed on 30 Jan 2026 to end their 1 Jun 2021 License and Collaboration Agreement for rocatinlimab (KHK4083, AMG 451); Amgen determined to discontinue its participation; Kyowa Kirin takes sole responsibility, at its own cost, for worldwide development, manufacture, regulatory work and commercialization |
| 3 Feb 2026 | Ex 99.1 | Q4 and FY 2025 results | Q4 2025 total revenues $9.87bn (+9%); product sales $9.37bn (+7%) on 10% volume growth and 4% lower net selling price; FY2025 total revenues $36.75bn (+10%); 14 products above $1bn of annual sales; GAAP EPS $14.23 (+88%); non GAAP EPS $21.84 (+10%) |
| 19 Feb 2026 | Ex 1.1 | Underwriting Agreement for $4.0bn senior notes | Dated 17 Feb 2026 with BofA Securities, Citigroup, J.P. Morgan and Morgan Stanley as representatives of the underwriters; Amgen receives 99.547% of principal for the 2031 notes, 99.377% for 2036, 98.866% for 2046 and 99.053% for 2056 |
| 19 Feb 2026 | Ex 4.2 | Officer's Certificate setting terms of the 2031, 2036, 2046 and 2056 notes | Initial offering prices: 99.897% (2031), 99.827% (2036), 99.616% (2046) and 99.928% (2056) of principal; Interest paid semiannually on 19 Feb and 19 Aug from 19 Aug 2026; notes issued under the 22 May 2014 indenture with The Bank of New York Mellon Trust Company as trustee |
| 19 Feb 2026 | Ex 5.1 | Latham & Watkins legal opinion on the notes | Opinion dated 19 Feb 2026 that the $4.0bn of notes are duly authorized and, once issued against payment, legally valid and binding obligations of Amgen; Covers New York law and the Delaware General Corporation Law only; registration statement on Form S 3 No. 333 293477 filed 13 Feb 2026 |
| 22 Apr 2026 | Ex 99.1 | Retirement of CTO David Reese and organizational changes | David M. Reese, EVP and Chief Technology Officer, retires effective 30 Jun 2026 after joining Amgen in 2005; he led R&D from 2018 to 2023; From 1 Jun 2026 James Bradner becomes EVP, Research and Development, AI and Data; Sean Bruich becomes SVP, Chief Technology Officer |
| 30 Apr 2026 | Ex 99.1 | Q1 2026 results | Q1 2026 total revenues $8.62bn (+6%); product sales $8.22bn (+4%) on 9% volume growth, 2% lower net selling price and 2% lower inventory; GAAP EPS $3.34 (+4%); non GAAP EPS $5.15 (+5%); non GAAP operating margin 45.3% (0.4 points lower); free cash flow $1.5bn vs $1.0bn |
| 19 May 2026 | Ex 99.1 | CFO Peter Griffith retires; Thomas Dittrich returns as CFO | Peter Griffith, CFO since 2020, steps down as CFO effective 31 Aug 2026 and stays as a non executive officer EVP until 31 Jan 2027; Thomas Dittrich, 62, former CFO of Galderma, Shire and Sulzer and Amgen Chief Accounting Officer from 2010 to 2014, joins 1 Jul 2026 and becomes CFO on 1 Sep 2026 |
| 19 May 2026 | Ex 10.1 | Employment Offer Agreement with Thomas Dittrich | Base salary CHF 1.07m with a target bonus of 100% of salary under the Global Management Incentive Plan; 2026 long term incentive target CHF 4.5m: options CHF 1.35m, RSUs CHF 900,000 and 2026 to 2028 performance units CHF 2.25m |
| 19 May 2026 | Ex 10.2 | Expatriate Assignment Letter of Understanding for Thomas Dittrich | Assignment to Thousand Oaks from 1 Sep 2026, employed by Amgen International AG and seconded to Amgen Inc.; Initial phase expected to last up to 48 months; base salary CHF 1.07m; standard EVP relocation benefits plus a CHF 250,000 relocation allowance (8 K Item 5.02) |
| 20 May 2026 | Item 5.07 text | 2026 annual meeting vote results | All 12 director nominees elected at the 19 May 2026 meeting; support for CEO Robert Bradway 95.0% and Greg Garland 94.8% of votes cast, the two lowest; Say on pay approved with 97.1% of votes cast (399.3m for, 12.0m against) |
| 31 Jul 2026 | Item 1.05 text | Material cybersecurity incident in third party cloud environments | In Jul 2026 Amgen identified unauthorized activity involving data stored in cloud environments hosted by third party providers; Some data, including proprietary data and patient protected health information, was exfiltrated; no impact found on products, manufacturing or financial reporting systems |
| 4 Aug 2026 | Ex 99.1 | Q2 2026 results | Q2 2026 total revenues $10.05bn (+10%); product sales $9.54bn (+9%) driven by volume; 22 products grew at least 10%; GAAP EPS $4.37 (+65%); non GAAP EPS $6.29 (+4%); non GAAP operating margin 48.4% (0.5 points lower); free cash flow $3.5bn vs $1.9bn |
| 26 Oct 2026 | Ex 99.1 | David W. Gibbs appointed to the board | Former Yum! Brands CEO (2020 to 2025) joins the board on 26 Oct 2026 and sits on the Audit and Compensation and Management Development committees; Board grows to 13 directors, 12 independent; standard pay of $115,000 cash retainer, $12,500 committee retainers and a $220,000 annual RSU grant, prorated (8 K Item 5.02) |
| 3 Nov 2026 | Ex 99.1 | Q3 2026 results | Q3 2026 total revenues $10.37bn (+8%); product sales $9.88bn (+8%) driven by volume; 17 products annualizing above $1bn; GAAP EPS $7.08 (+19%); non GAAP EPS $6.45 (+14%); GAAP operating margin 37.5% (+9.9 points); non GAAP operating margin 47.3% (+0.2 points) |